Separation of salts of citric acid from fermentation broth with

Details Separation of salts of citric acid from fermentation broth with Separation of salts of citric acid from fermentation broth with

1988-11-25

1990-05-08

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 5142

Patent

active

049240277

ABSTRACT:
Salts of citric acid are separated from a fermentation broth by a two-step process utilizing an adsorbent comprising a water-insoluble, macroreticular gel, weakly basic, anionic exchange resin possessing tertiary amine functional groups or pyridine functional groups, said anionic exchange resin comprising a crosslinked acrylic or styrene resin matrix and a desorbent comprising water or dilute sulfuric acid. The pH of the feed, a fermentation broth, containing citric acid, is adjusted and maintained below the first ionization constant (pKa.sub.1) of citric acid to maintain selectivity in the first step wherein citric acid is adsorbed onto the adsorbent. Then, citric acid is converted to a salt by a reaction with an aqueous alkaline liquid solution and is eluted immediately at the void volume in the alkaline solution.

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patent: 4720579 (1988-01-01), Kulprathipanja
Johnson, J., Sci. Food Agric., vol. 33(3) pp. 287-293, Handbook of Chemistry & Physics, 53rd Ed. 1972-3 CRC Press.

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