Separation of enantiomers of non-steroidal anti-inflammatory dru

Liquid purification or separation – Processes – Liquid/liquid solvent or colloidal extraction or diffusing...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

210656, 2101982, 2105021, 502401, 502439, B01D 1508

Patent

active

052562930

ABSTRACT:
The invention relates to a chiral selector useful in separating underivatized enantiomers of nonsterodial anti-inflammatory agents, particularly naproxen and other arylacetic acid compounds, and relates to a process for achieving such separation utilizing the chiral selector, which is also useful in achieving the enantiomeric separation of amines, alcohol derivatives, epoxides and sulfoxides. The invention is also directed to an apparatus which comprises the chiral selectors.

REFERENCES:
patent: 4318819 (1982-03-01), Malloy
patent: 4318820 (1982-03-01), Malloy
patent: 4322310 (1982-03-01), House
patent: 4512898 (1985-04-01), Oi
patent: 4604207 (1986-08-01), Oi
patent: 4818394 (1989-04-01), Okamoto
patent: 4824950 (1989-04-01), Barcza
patent: 4909935 (1990-03-01), Bradshaw et al.
patent: 4919803 (1990-04-01), Doyle et al.
patent: 5080795 (1992-01-01), Pirkle
Wainer, et al., "Resolution of Norephedrine as its 2-oxazolidone Derivative: Enantiomeric Separation on a Chiral High-Performance Liquid Chromatographic Stationary Phase and Preparative Regeneration of the Resolved Isomers", 268, J. of Chromatogr., 107-111 (1983).
Wainer, et al., "Application of High-Performance Liquid Chromatographic Chiral Stationary Phases to Pharmaceutical Analysis: Structural and Conformational Effects in the Direct Enantiomeric Resolution of .alpha.-Methylarylacetic Acid Anti-Inflammatory Agents", 284, J. of Chromatogr., 117-124 (1984).
Yang, et al., "Application of High-Performance Liquid Chromatographic Chiral Stationary Phases to Pharmaceutical Analysis: Resolution of Enantiomeric Barbiturates, Succinimides and Related Molecules on Four Commercially Available Chiral Stationary Phases", 324, J. of Chromatogr., 444-449 (1985).
"One Optical Isomer Without the Other", Chemical Week, 28-29, Feb. 13, 1985.
Doyle, "Analytical Criteria for Chiral HPLC: Where We Are Now", Anyl. Item 44 (Undated).
Doyle, et al., "The Resolution of Enantiomeric Drugs Using HPLC Chiral Stationary Phases", Pharmaceutical Technology, 28-32, (Feb. 1985).
Wainer, et al., "The Application of HPLC Chiral Stationary Phases to Pharmaceutical Analysis: The Resolution of Some Tropic Acid Derivatives", 7(4), J. of Liquid Chromatogr., 731-741 (1984).
Perry, et al., "Chiral Separations by HPLC. Theory and Practice: Developments with the Pirkle Covalent JPLC Column", No. 939 (Undated).
Wainer, et al., "Stereoisomeric Separations: Use of Chiral Stationary Phases to Resolve Molecules of Pharmacological Interest", 2, No. 2, LC, 88-89 (Undated).
Hermansson, et al., "Direct Liquid Chromatographic Resolution of Acidic Drugs Using a Chiral .alpha.1-Acid Glycoprotein Column (Enantiopac.RTM.)", 9(2 & 3), J. of Liquid Chromatogr., 621-639 (1986).
Pettersson, et al., "Improved Resolution of Enantiomers of Naproxen by the Simultaneous Use of a Chiral Stationary Phase and a Chiral Additive in the Mobile Phase", 435, J. of Chromatogr., 225-228 (1988).
Bojarski, "Chromatography of Enantiomers of 2-Arylpropionic Acids", 12(14), 2685-2706 (1989).
Pirkle, et al., "The Separation of the Enantiomers of a Variety of Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) as Their Anilide Derivatives Using a Chiral Stationary Phase", 13(11), J. of Liquid Chromatogr., 2123-2134 (1990).
Pirkle, et al., "Improved Chiral Stationary Phase for the Separation of the Enantiomers of Chiral Acids as Their Anilide Derivatives", 471, J. of Chromatogr., 271-281 (1989).
Pirkle, et al., "A Chiral Stationary Phase Which Affords Unusually High Levels of Enantioselectivity", 3, Chirality, 183-187 (1991).
Pirkle, et al., "Use of Achiral Ion-Pairing Reagents with Chiral Stationary Phases", 479, J. of Chromatogr., 377-386 (1989).
Pirkle, et al., "An Improved Chiral Stationary Phase for the Facile Separation of Enantiomers", 441, J. of Chromatogr., 311-322 (1988).
Ru
This invention was made with Government support under Grant CHE-8714950 awarded by the National Science Foundation. The Government has certain rights in the invention.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Separation of enantiomers of non-steroidal anti-inflammatory dru does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Separation of enantiomers of non-steroidal anti-inflammatory dru, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Separation of enantiomers of non-steroidal anti-inflammatory dru will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-956623

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.