Liquid purification or separation – Processes – Chromatography
Patent
1979-06-14
1981-09-22
Adee, John
Liquid purification or separation
Processes
Chromatography
2101982, B01B 1508
Patent
active
042908930
ABSTRACT:
An aqueous eluant containing a chiral ligand and a suitable metal ion effects the separation of enantiomers on a non-chiral support. The stereoselectivity is ascribed to differences in stability and/or different partition coefficient of the diastereomeric inner sphere complex formed in solution.
REFERENCES:
patent: 4133753 (1979-01-01), Takbuchi
Separation of Phenolic Compounds by Anion Exchange Resin in Copper Chloride (11) Organic Solvent System by Lee et al., Analytical Chem. vol. 45, No. 2, 2/1973, pp. 396-399.
Resolution of the Optical Isomers of Dansyl Amino Acids by Reverse Phase Liquid Chromatography with Optically Active Metal Chelate Additives by Page et al., Analytical Chemistry, vol. 51, No. 3, 3/1979, pp. 433-435.
Resolution of Optical Isomers by Liquid Chromatography by Pirkle et al. Journal of Chromatography, 123 (1976), pp. 400-404.
Chromatographic Study of Optical Resolution by Nakazawa et al., Journal of Chromatography 160 (1978) pp. 89-99.
Ligand Chromatography and the Preparation of Optically Active Compounds by Davankov in Soviet Science Review, vol. 3, No. 6, Nov. 1972, pp. 352-356.
Davankov, V.A. et al. "Ligand-Exchange Chromatography of Racemates; VI. Separation of Optical Isomers of Aminoacids on Polystyrene Resin Containing L-proline or L-azetidine Carboxylic Acid," J. Chrom., 155 (2) 295-302, 1978.
Gil-Av, E. et al. "Resolution of Underivatized Aminoacids by Reversed-Phase Chromatography," J. Am. Chem. Soc., 102, 5115-5117 (1980).
Gil-Av E.
Hare P. Edgar
Adee John
Yeda Research & Development Co. Ltd.
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