Separation of acetaldehyde-induced hemoglobin (Hb A.sub.1-AcH)

Details Separation of acetaldehyde-induced hemoglobin (Hb A.sub.1-AcH) Separation of acetaldehyde-induced hemoglobin (Hb A.sub.1-AcH)

1993-05-18

1995-10-24

Czaja, Donald E

Chemistry: analytical and immunological testing

Hemoglobin, myoglobin, or occult blood

436 67, 436128, 436132, 436161, 422 70, G01N 3372

Patent

active

054609704

ABSTRACT:
A chromatographic method used to detect chronic alcohol usage and alcoholism and to monitor alcohol rehabilitation treatment; the method provides improved resolution of the Hb A.sub.1-AcH peak from the contiguous Hb A.sub.1c peak by means of a polyaspartic acid chromatographic column and a nonlinear buffer gradient; the resulting Hb A.sub.1-AcH peak is then evaluated to determine chronic alcohol usage which is indicative of alcoholism and which can be used to monitor alcohol rehabilitation treatment.

REFERENCES:
patent: 4468330 (1984-08-01), Kamiyama et al.
patent: 4473640 (1984-09-01), Combie et al.
patent: 4517241 (1985-05-01), Alpert
patent: 4777132 (1988-10-01), Green et al.
patent: 4814280 (1989-03-01), Peterson
patent: 4837157 (1989-06-01), Turnell et al.
patent: 4855054 (1989-08-01), Williams
patent: 4980058 (1990-12-01), Bruegger
Huisman, et al., A new high-performance liquid chromotographic procedure to quantitate hemoglobin Al.sub.c, J. Lab Clin Med 102:163-173 (1983).
Peterson, et al., Artefactual Increase in Hemoglobins, Alcoholism: Clin Exp Res 10:219-220 (1986).
Homaidan et al., Acetaldehyde-Hemoglobin Adducts, Clin Chem 30/3, 480-482 (1984).
Sillanaukee, et al., Association of a Haemglobin-Acetaldehyde Adduct with Questionnaire Results on Heavy Drinkers, Alcohol 26: 519-525 (1991).
Sillanaukee et al., Acetaldehyde Modified Hemoglobin as a Marker of Alcohol Consumption, J Clin Med 1992; 120:42-7.
Sillanaukee et al., Effect of Acetaldehyde on Hemoglobin, Alcohol 8(5) 377-381, 1991.
Sillanaukee and Koivula, Detection of a New Acetaldehyde-Induced Hemoglobin Fraction, Alcohol Clin Exp Res 1990; 14: 842-846.
Bisse and Wieland, High-Performance Liquid Chromatographic Separation of Human Haemoglobins, J. Chrom, 434 (1988) 95-110.
Willard et al. "Instrumental Methods of Analysis" 1981 pp. 495-501.

Affiliated with

Also associated with

Rating

Separation of acetaldehyde-induced hemoglobin (Hb A.sub.1-AcH) does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Separation of acetaldehyde-induced hemoglobin (Hb A.sub.1-AcH), we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Separation of acetaldehyde-induced hemoglobin (Hb A.sub.1-AcH) will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1886140