Separation material derived from glucomannan for blood coagulati

Details Separation material derived from glucomannan for blood coagulati Separation material derived from glucomannan for blood coagulati

1990-12-18

1992-03-17

Dawson, Robert A.

Liquid purification or separation

Processes

Chromatography

2101982, 2105021, 436513, 436529, 502402, 502404, 530381, 530383, 530413, B01D 1508

Patent

active

050965930

ABSTRACT:
The separation material for separating and recovering a blood coagulation factor comprises a porous matrix having linked thereon one or more ligands each consisting of a radical exhibiting an affinity for the blood coagulation factor to be recovered, said matrix having a specific surface area of at least 1.5 m.sup.2 per milliliter of the separation material with respect to pores having diameters of at least 0.1 .mu.m and being derived from a porous particulate material having an exclusion limit molecular weight of at least 1.5.times.1.sup.6 as determined with polyethylene glycol. The separation material is prepared by the process steps of subjecting a porous particulate material having an exclusion limit molecular weight of at least 1.5.times.10.sup.6 to activation by 1,1'-carbonyldiimidazolating, tresylating, carbodiimidizing, thiopropylating, epoxidizing, bromocyanizing or formylating using the corresponding activating agent and reacting the so activated porous particulate material with one or more substances which exhibit after being linked as ligand on the porous particulate material, an affinity to the blood coagulation factor to be covered, so as to form a porous matrix having a specific surface area of at least 1.5 m.sup.2 per milliliter of the porous particulate material with respect to pores having diameters of at least 0.1 .mu.m.

REFERENCES:
patent: 4675385 (1987-06-01), Herring
patent: 4882426 (1989-11-01), Motozato
patent: 4883598 (1989-11-01), Riethorst et al.
patent: 4948814 (1990-08-01), Motozato et al.
L. R. Snyder and J. J. Kirkland, "Introduction to Modern Liquid Chromatography", 2nd Ed., Wiley, New York (1979), pp. 192-195, 203.

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