Separation column for liquid chromatography and sealing arrangem

Details Separation column for liquid chromatography and sealing arrangem Separation column for liquid chromatography and sealing arrangem

1981-06-05

1982-09-21

Adee, John

Liquid purification or separation

Processes

Chromatography

55386, 2101982, 210351, 210352, B01D 1508

Patent

active

043505953

ABSTRACT:
A separation column for liquid chromatography is adjustably sealed for reducing dead space therein. The separation column is packed and an elastic diaphragm seals one end. There is spherically shaped inert material located between the packing and the elastic diaphragm with a porous frit located between the inert material and the diaphragm. A piston exerts a force on the diaphragm to stretch it longitudinally into the column thereby reducing the dead space. The frit and inert material operate to uniformly distribute the force exerted by the piston.

REFERENCES:
patent: 62505 (1867-02-01), Simmons
patent: 847518 (1907-03-01), Shiltz
patent: 3511377 (1970-05-01), Hrdina
patent: 3680707 (1972-08-01), Zeek
patent: 4093548 (1978-06-01), Starkenburg

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