Separation and quantitation of coproporphyrins and uroporphyrins

Details Separation and quantitation of coproporphyrins and uroporphyrins Separation and quantitation of coproporphyrins and uroporphyrins

1978-12-01

1980-12-02

Marantz, Sidney

Chemistry: physical processes

Physical processes

Crystallization

23230, G01N 3106, G01N 3108, G01N 3372, G01N 2164

Patent

active

042368928

ABSTRACT:
Urinary porphyrin levels are assayed as a diagnosis technique for many disorders and abnormalities. Selective separation and quantitation of coproporphyrins (COPRO) and uroporphyrins (URO) are accomplished by adsorbing urine on an anionic exchange resin and selectively eluting the COPRO then the URO from the resin, followed by the determination of the amount of COPRO or URO in the respective eluates. In preferred methods the COPRO eluate is a diluted HCl and the eluate for URO is a more concentrated HCl; and the amount of COPRO or URO is determined quantitatively by fluorometric comparison with known concentrations of COPRO.

REFERENCES:
M. I. Walters, Am. Clin. Lab. Sci., 4(1), 29-35, (1974).
Chemical Abstracts, 83:4091s (1975).
"Ion Exchangers in Org. and Biochem.", C. Calmon et al., eds., 335-337, Interscience, New York, 1957.
R. L. Searcy, "Diagnostic Biochemistry", 421-422, McGraw-Hill, New York, 1969.

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