Chemistry: analytical and immunological testing – Optical result – With fluorescence or luminescence
Patent
1995-01-18
1996-03-12
Housel, James C.
Chemistry: analytical and immunological testing
Optical result
With fluorescence or luminescence
422 55, 422 58, 422 8205, 422 8208, 422 8211, 436 68, 436178, G01N 2164, G01N 2177
Patent
active
054985498
ABSTRACT:
A sensor for measuring the concentration of an analyte in a medium is disclosed. In one embodiment, the sensor comprises a sensing element including a matrix material and, covalently bonded thereto, one or more monomeric indicator components each of which is capable of providing a first emitted signal of a given wavelength in response to being exposed to an excitation signal. The sensing element is capable of providing a second emitted signal having a longer wavelength than the first emitted signal or signals in response to being exposed to the excitation signal, the second emitted signal being provided by an excimer component produced in the sensing element from the monomeric indicator component(s) and being dependent on the concentration of the analyte in the medium to a greater extent than the first emitted signal or signals. In another embodiment, the sensor comprises a sensing element including two or more different monomeric components at least one or which is a monomeric indicator component capable of providing a first emitted signal in response to being exposed to a first excitation signal. The sensing element is capable of providing a second emitted signal in response to being exposed to a second excitation signal. This second emitted signal is provided by an exciplex produced from the monomeric components. This second emitted signal is preferably dependent on the concentration of the analyte in the medium. An excitation assembly is positioned and adapted to provide the excitation signal to the sensing element. A detector assembly is positioned and adapted to detect the second emitted signal. Preferably, a processor assembly is positioned and adapted to analyze the second emitted signal in determining the concentration of the analyte in the medium.
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Bentsen James G.
Dektar John L.
Katritzky Alan R.
Kipke Cary A.
Nagel Colleen C.
Griswold Gary L.
Housel James C.
Kirn Walter N.
Le Long V.
Minnesota Mining and Manufacturing Company
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