Sensor with improved drift stability

Details Sensor with improved drift stability Sensor with improved drift stability

1993-11-30

1995-04-04

Housel, James C.

Chemistry: analytical and immunological testing

Blood gas

436163, 436172, 436133, 422 8204, 422 8207, 422 8208, 73 2321, 2524081, G01N 3350, G01N 3100

Patent

active

054037468

ABSTRACT:
The present invention provides an optical fluorescence based sensor for measuring the concentration of a gas (e.g., CO.sub.2 or ammonia) in a medium such as blood which has improved drift stability. In a preferred embodiment, the sensors of the present invention comprise microcompartments of an aqueous phase having a pH sensitive sensing component within a hydrophobic barrier phase. The sensors of the present invention are substantially free of partitioning species other than the analyte of interest which can migrate from one phase to the other in response to a change in pH in the aqueous phase and which substantially affect the concentration dependent signal. In an alternative embodiment, the sensors of the present invention are constructed so as to retard the migration of partitioning species, thus reducing the initial rate of drift.

REFERENCES:
patent: Re31879 (1985-05-01), Lubbers et al.
patent: 4041932 (1977-08-01), Fostick
patent: 4510094 (1985-04-01), Drahnak
patent: 4530879 (1985-07-01), Drahnak
patent: 4557900 (1985-12-01), Heitzmann
patent: 4600484 (1986-07-01), Drahnak
patent: 4640820 (1987-02-01), Cooper
patent: 4824789 (1989-04-01), Yafuso et al.
patent: 4833091 (1989-05-01), Leader et al.
patent: 4840485 (1989-06-01), Gratton
patent: 4849172 (1989-07-01), Yafuso et al.
patent: 4851195 (1989-07-01), Matthews et al.
patent: 4867919 (1989-09-01), Yafuso et al.
patent: 4916169 (1990-04-01), Boardman et al.
patent: 4943364 (1990-07-01), Koch et al.
patent: 4989606 (1991-02-01), Gehrich et al.
patent: 5006247 (1991-04-01), Dennison et al.
patent: 5056520 (1991-10-01), Tomisaka et al.
patent: 5114676 (1992-05-01), Leiner et al.
patent: 5204265 (1993-04-01), Nelson et al.
patent: 5219527 (1993-06-01), Hui et al.
patent: 5246859 (1993-09-01), Nelson et al.
patent: 5284775 (1994-02-01), Yatuso et al.
"A Fiber-Optic Sensor for CO.sub.2 Measurement", Munkholm and Walt, Talanta, vol. 35, No. 2, pp. 109-112 (1988).
"Fiber-Optic Fluorosensor for Oxygen and Carbon Dioxide", Wolfbeis and Weis, Anal. Chem., 1988, 60, pp. 2028-2030.
"Fibre-Optic Fluorescing Sensor for Ammonia", Wolfbeis and Posch, Analytica Chimica Acta, 185 (1986) pp. 321-327.
Richard P. Haugland, "Handbook of Fluorescent Probes and Research Chemicals", 5th Edition, pp. 129-141 (1992).

Affiliated with

Also associated with

Rating

Sensor with improved drift stability does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sensor with improved drift stability, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sensor with improved drift stability will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2380158