Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is inorganic
Patent
1984-11-28
1988-04-05
Marantz, Sidney
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is inorganic
324 711, 367157, 436501, 436518, 436806, G01N 3353, H01L 4100
Patent
active
047359064
ABSTRACT:
A sensor and method for performing immunoassays using surface acoustic waves on a piezoelectric crystal is provided. A specific antigen or antibody is bonded to the surface of the piezoelectric crystal and its resonant frequency in a blank solution is determined. The sensor is then exposed to a test solution containing an antigen or antibody corresponding to the substance bonded to the surface of the crystal. As the antigen and antibody react, the resonant frequency of the crystal is altered. This change can be correlated to determine the amount of antigen or antibody in the test solution. A nonreactive reference sensor can also be used to compensate for any nonselective adsorption.
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Marantz Sidney
Texas A&M University
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