Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1992-09-16
1994-12-13
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
250306, 250307, 422 50, 422 681, 435 71, 435291, 436501, 436518, 436524, 436525, 436527, 436531, 436532, G01N 33543
Patent
active
053729307
ABSTRACT:
A sensor for ultra-low concentration chemical recognition comprises a force transducer, a tip coupled to this force transducer, and a substrate positioned for force interaction with the force transducer tip, where the substrate and tip are chemically modified with antigens, antibodies, nucleic acids, or chelating agents so that there is a specific force interaction between the tip and the substrate in the presence of the target species, and a measurably different force interaction in the absence of the target species.
REFERENCES:
patent: 5047633 (1991-09-01), Finlan et al.
patent: 5106729 (1992-04-01), Lindsay et al.
Masai et al., "Scanning Tunneling: Microscopic Immunoassay: A Preliminary periment", J. Vacuum Sci. Technology, A8(1), (Jan./Feb. 1990), pp. 713-717.
Haussling et al., "Biotin Functionalized Self-Assembled Monolayers on Gold: Surface Plasmon Optical Studies of Specific Recognition Reactions", Langmuir: ACS J. Surfaces & Colloids, 7(9), (Sep. 1991), pp. 1837-1840.
Prime et al., "Self-Assembled Organic Monolayers: Model Systems for Studying Adsorption of Proteins at Surface", Science, 252, (May 24, 1991), pp. 1164-1167.
Evans et al., "Detachment of Agglutinin Bonded Red Blood Cells I: Forces to Rupture Molecular Point Attachments", Biophysical J., 59, (Apr. 1991), pp. 838-848.
Leckband et al., "Long Range Attraction and Molecular Rearrangements in Receptor-Ligand Interactions", Science, 255, (Mar. 13, 1992), pp. 1419-1421.
Helm et al., "Measurement of Ligand-Receptor Interactions", Biochemistry, 88, (Sep. 1991), pp. 8169-8173.
Ahlers et al., "Protein Interactions with Ordered Lipid Films: Specific and Unspecific Binding", Advanced Materials, 3, (1991), pp. 39-46.
Colton Richard J.
Kidwell David A.
Chi Christopher L.
Karasek John J.
McDonnell Thomas E.
Scheiner Toni R.
The United States of America as represented by the Secretary of
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