Sensor constructs and detection methods

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C356S317000, C356S318000, C356S417000, C250S458100, C250S459100, C250S461100, C250S461200, C435S006120, C436S164000, C436S166000, C436S172000, C530S350000

Reexamination Certificate

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11083461

ABSTRACT:
Sensor constructs for detecting the presence of an analyte in a sample comprise a molecular scaffold, a pair of labels which interact via Förster resonance energy transfer, and at least one molecular recognition domain. When the analyte is bound by the molecular recognition domain, the Förster resonance energy interaction between the pair of labels is disrupted, resulting in a changed optical signal.

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