Chemistry: analytical and immunological testing – Biospecific ligand binding assay
Patent
1994-05-20
1998-01-06
Chin, Christopher L.
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
73 6175, 73 6453, 73579, 73580, 310311, 310312, 310313R, 310313A, 310340, 310361, 310365, 310367, 310369, 422 681, 422 8201, 435 71, 4352831, 4352872, 436518, 436524, 436525, 436527, G01N 33543, G01N 33551, G01N 33552
Patent
active
057053995
ABSTRACT:
A chemical sensor for measuring a change in the sensor mass relating to the interaction of a surface of the sensor with a solution comprises a crystal detector oscillator capable of providing a measurement signal based upon the resonant frequency of the crystal detector oscillator. The crystal detector oscillator has a first crystal side for directly contacting the solution, and a second crystal side isolated from contacting the solution. A first electrode is integral to the first crystal side, with the first electrode having an inner and outer perimeter defining an outer portion of the first crystal side which is exterior to the outer perimeter of the first electrode and an inner portion of the first crystal side which is interior to the inner perimeter of the first electrode. A second electrode is integral to the second crystal side. The sensor may be employed to detect the concentration of predetermined species in solution by adsorbing a predetermined species-specific complementary material such as an antibody onto the active crystal sites of the first crystal side, and thereafter contacting the first crystal side with the species-containing solution. The sensor may also be used to measure the change in sensor mass relating to the degradation of a coating applied to the first crystal side thereof.
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Chin Christopher L.
The Cooper Union for Advancement of Science and Art
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