Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2011-05-10
2011-05-10
Vivlemore, Tracy (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C514S04400A, C435S320100
Reexamination Certificate
active
07939653
ABSTRACT:
The invention relates to the identification of genes involved in resistance of cancer cells to therapy, to short nucleic acid molecules which inhibit the expression of these genes by RNA interference and to their use as adjuvant in cancer therapy, to sensitize cancer cells to conventional anticancer agents; the short nucleic acid molecules are double-stranded short interfering nucleic acid molecules including a sense and an antisense region, wherein the sense region includes a nucleotide sequence that is selected from the group consisting of: the sequences SEQ ID NO: 15, 11, 13, 14, 30, 31, 38, 46, 64 and 70 and the sequences having at least 70% identity, preferably at least 80% identity, more preferably at least 90% identity with the sequences, and the antisense region includes a nucleotide sequence that is complementary to the sense region.
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patent: 2006/0134189 (2006-06-01), MacLachlan et al.
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patent: 2005/123953 (2005-12-01), None
Chang, I.Y. et al., “Small Interfering RNA-Induced Suppression of ERCC1 Enhances Sensitivity of Human Cancer Cells to Cisplatin”, Biochemical and Biophysical Research Communications, Feb. 4, 2005, pp. 225-233, vol. 237, No. 1, Academic Press Inc., Orlando, FL XP004697918.
Selvakumaran, M. et al., “Enhanced Cisplatin Cytotoxicity by Disturbing the Nucleotide Excision Repair Pathway in Ovarian Cancer Cell Lines”, Cancer Research, American Association for Cancer Research, Mar. 15, 2003, pp. 1311-1316, vol. 63, No. 6 XP002321157.
EP Search Report dated Jan. 7, 2007 from corresponding EP 06291241.
Berger François
Boccard Sandra
Issartel Jean-Paul
Pelletier Laurent
Universite Joseph Fourier
Vivlemore Tracy
Young & Thompson
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