Sensitizing agents for use in boron neutron capture therapy

Details Sensitizing agents for use in boron neutron capture therapy Sensitizing agents for use in boron neutron capture therapy

1992-02-24

1995-04-11

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 177, 424 9, 514 64, 544229, 544238, 562 7, 562 20, 549333, 556436, 568 6, 568328, 568381, A61K 4100, A61K 4300, C07F 502, C07F 504

Patent

active

054055989

ABSTRACT:
Compounds of formula I and II ##STR1## in which B contains a carboranyl group and one of R.sub.3 and R.sub.4 is a carboranyl group or a boronic acid or ester are useful sensitizing agents for boron neutron capture therapy.

REFERENCES:
patent: H505 (1988-08-01), Slatkin et al.
patent: 4247474 (1981-01-01), Breslow
patent: 4959356 (1990-09-01), Miura et al.
patent: 5021572 (1991-06-01), Gabel
patent: 5066479 (1991-11-01), Hawthorne
patent: 5130302 (1992-07-01), Spielvogel et al.
Yamamoto et al, J. Chem. Soc., Chem. Commun., pp. 157-158 (1992).
Schinazi et al, J. Org. Chem., vol. 50, pp. 841-847, (1985).

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