Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing
Reexamination Certificate
2007-04-03
2007-04-03
Campell, Bruce R. (Department: 1648)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
C424S093200, C424S215100
Reexamination Certificate
active
10431579
ABSTRACT:
The present invention relates to methods of sensitizing neoplastic cells to irradiation by using oncolytic viruses, particularly reoviruses. Also provided are methods of treating or ameliorating a tumor with a combination of oncolytic viruses and radiotherapy.
REFERENCES:
patent: 6100243 (2000-08-01), Frisch
patent: 6136307 (2000-10-01), Lee et al.
patent: 6565831 (2003-05-01), Coffey et al.
patent: 2002/0037576 (2002-03-01), Thompson et al.
patent: WO 96/07322 (1996-03-01), None
patent: WO 00/50051 (2000-08-01), None
patent: WO 02/11742 (2002-02-01), None
patent: WO 02/066040 (2002-08-01), None
Bradley et al. Clinical. Cancer Research 1999, vol. 5, pp. 1517-1522.
Smith et al. Expert Opinion on Investigational Drug 2000, vol. 9, No. 2, pp. 311-327.
Bar-Eli, N., et al., “preferential cytotoxic effect of Newcastle disease virus on lymphoma cells”,J. Cancer Res. Clin. Oncol.122: 409-415 (1996).
Chandran and Nibert, “Protease cleavage of reovirus capsid protein mu1 and mu1C is blocked by alkyl sulfate detergents, yielding a new type of infectious subvirion particle”, J. of Virology 72(1):467-75 (1998).
Chang et al.,PNAS89:4825-4829 (1992).
Chang, H.W. et al.,Virology194:537-547 (1993).
Chang et al.,J. Virol.69:6605-6608 (1995).
Chmura et al., “Strategies for enhancing viral-based gene therapy using ionizing radiation”, Radiation oncology Investigations 7:261-269 (1999).
Chmura et al., “Prospects for viral-based strategies enhancing the anti-tumor effects of ionizing radiation”, Seminars in Radiation Oncology 11(4):338-345 (2001).
Cuff et al., “Enteric reovirus infection as a probe to study immunotoxicity of the gastrointestinal tract”,Toxicological Sciences42(2):99-108 (1998).
Duncan et al., “Conformational and functional analysis of the C-terminal globular head of the reovirus cell attachment protein”, Virology 182(2):810-9 (1991).
Fueyo, J., et al., “A Mutant Oncolytic Adenovirus Targeting the Rb Pathway Produces Anti-Glioma Effectin Vivo”, Oncogene19(1):2-12 (2000).
Kawagishi-Kobayashi, M., et al.,Mol. Cell. Biology17:4146-4158 (1997).
Mah et al., “The N-terminal quarter of reovirus cell attachment protein sigma 1 possesses intrinsic virion-anchoring function”, Virology 179(1):95-103 (1990).
Nemunaitis, J.,Invest. New Drugs17:375-386 (1999).
Nibert, M.L., Schiff, L.A., and Fields, B.N., “Reoviruses and their replication”, pp. 1557-1596 inFundamental Virology(Fields et al., 3rd Edition), Lippencott-Raven Press, 1996.
Reichard, K.W., et al., “Newcastle Disease Virus Selectively Kills Human Tumor Cells”,J. of Surgical Research52:448-453 (1992).
Romano et al.,Mol. and Cell. Bio.18:7304-7316 (1998).
Sharp et al.,Virol.250:301-315 (1998).
Turner and Duncan, “Site directed mutagenesis of the C-terminal portion of reovirus protein sigmal: evidence for a conformation-dependent receptor binding domain”, Virology 186(1):219-27 (1992).
Yoon, S.S., et al., “An Oncolytic Herpes Simplex Virus Type I Selectively Destroys Diffuse Liver Metastases from Colon Carcinoma”,FASEB J.. 14:301-311(2000).
Zorn, U. et al., “Induction of Cytokines and Cytotoxicity against Tumor Cells by Newcastle Disease Virus”,Cancer Biotherapy9(3):22-235 (1994).
Abstract, Oncogene, Oct. 18, 2001;20(47):6910-9, “Caspase 8-dependent sensitization of cancer cells to TRAIL-induced apoptosis following reovirus-infection”.
Ball Douglas
Coffey Matthew C.
Morris Donald
Thompson Bradley G.
Li Bao Qun
Oncolytics Biotech Inc.
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