Sensitization of hypoxic tumor cells and control of growth there

Surgery – Radioactive substance applied to body for therapy

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424320, 424325, 128804, A61N 130

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active

048895253

ABSTRACT:
Method of sensitizing hypoxic tumor cells to radiotherapy and chemotherapy by contacting the cells or the vasculature thereof with an aqueous dispersion of an oxygen carrying perfluoro compound and a dispersant for the compound, and sensitizing chemotherapeutic and protective compositions therefor.

REFERENCES:
patent: Re32393 (1987-04-01), Wretlind et al.
patent: 3453333 (1969-07-01), Litt et al.
patent: 3778381 (1973-12-01), Rosano et al.
patent: 3828085 (1974-08-01), Price et al.
patent: 4073943 (1978-02-01), Wretlind et al.
patent: 4168308 (1979-09-01), Wretlind et al.
patent: 4241060 (1980-12-01), Smithen
patent: 4282232 (1981-08-01), Agrawal
patent: 4325972 (1982-04-01), Geyer et al.
patent: 4366169 (1982-12-01), White
patent: 4445500 (1984-05-01), Oskorholm
Riess et al., "Perfluoro Compounds as Blood Substitutes", Angewandte Chemie (Int. Ed.), 17 (9), 621-634, 9/1978.
Goldenberg et al., "Direct and Abscopal Antitumor Action . . . ", Zeitschrift fur Natur Forschug, Apr. 1977, pp. 359-361.
Crile, "Effects of Heat and Radiation on Cancers . . . ", Cancer Research, vol. 23, Mar., 1963, pp. 372-380.
Stehlin et al., "Results of Hyperthermic Perfusion . . . ", Surgery, Gyn. & Obs., vol. 140, No. 3, Mar., 1975, pp. 339-347.
"Radiopaque Applications of Brominated Fluorocarbon Compounds in Experimental Animals and Human Subjects," D. M. Long et al., appearing in Biochemistry Involving Carbon-Fluorine Bonds, edited by R. Fuller, ACS Symposium Series No. 28, 171-189, (1976).
Chemical Abstracts, vol. 87, No. 23, Dec. 5th, 1977, p. 278, No. 181618x, Columbus, Ohio, U.S.A., T. Matsumoto et al., "Role on Oncotic Agents in Saving Effect of Perfluorochemical Emulsions in Hemodilution", Chem. Pharm. Bull. 1977, 25 (9), 2163-2171.
Chemical Abstract, vol. 79, No. 13, Dec. 1st, 1973, p. 45, No. 73792a, Columbus, Ohio, U.S.A., R. Esaki et al.: "Sensitivity of Anticancer Drugs and Their Concentration in Tissues", Advan. Antimicrob. Antineoplastic Chemother., Proc. Int. Congr. Chemother., 7th, 1971, (Pub. 1972), 2, 383-386.
Chemical Abstracts, vol. 97, No. 11, Sep. 13th, 1982, p. 55, No. 84920p, Columbus, Ohio, U.S.A., T. Kokunai et al.: "Effect of Perfluorochemicals on BCNU Chemotherapy in a Rat Brain-Tumor Model", Brain Nerve, 1982, 34(6), 609-615.
Chemical Abstracts, vol. 97, No. 23, Dec. 6th, 1982, pp. 26, 27, No. 192822s, Columbus, Ohio, U.S.A., J. Neurosurg., 1982, 57(4), 467-471.
Chemical Abstracts, vol. 96, No. 12, Mar. 1982, pp. 400, 401, No. 91568n, Columbus, Ohio, U.S.A., N. Markina et al.: "Emulsifying Capacity of Sodium Deoxycholate in Regards to Perfluorocarbons in the Aqueous Phase", Perftorirovannye Uglerody Biol. Med., 1980, 67-75.
The Merck Index, 1976, pp. 359, 371, 782, 1282.
Kokunai et al., Brain & Nerve, 34(6): 609-615, 1982, Effect of Perfluorochemicals on BCNU Chemotherapy in a Rat Brain-Tumor Model.

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