Sensitive tests for malignancies based on DNA detection

Details Sensitive tests for malignancies based on DNA detection Sensitive tests for malignancies based on DNA detection

1984-09-13

1988-09-27

Warren, Charles F.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

436518, 436813, 436808, 436501, 435803, 435810, C12Q 168, G01N 33566, G01N 33543

Patent

active

047741767

ABSTRACT:
A more convenient, more sensitive test for detection of certain malignancies in human and animal subjects is disclosed. Sera from test subjects is mixed with labeled DNA in the presence of an enzyme-conjugated matrix. Sera from normal and cancerous subjects react differently with the matrix, permitting a diagnosis of the subject.

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Gottlieb, A. A. et al, Cancer Research, vol. 40, 1980, pp. 758-770.

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