Sensitive proteasome sensor constructs and methods for their...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S325000, C530S350000, C536S023400

Reexamination Certificate

active

10765244

ABSTRACT:
Provided are means and methods for sensing proteasome activity and other degradation pathways with a high level of sensitivity.

REFERENCES:
patent: 6183776 (2001-02-01), Depui et al.
patent: 2002/0197676 (2002-12-01), Lukyanov et al.
patent: WO 01/81427 (2001-11-01), None
Li et al., The Journal of Biological Chemistry, vol. 273, 1998, pp. 34970-34975.
Adams et al. “Proteasome Inhibitors: A Novel Class of Potent and Effective Antitumor Agents,” Cancer Research (1999) 59:2615-2622.
Gurskaya et al. “GFP-Like Chromoproteins as a Source of Far-Red Fluorescent Proteins,” FEBS Letters (2001) 507:16-20.
Rogers et al. “Amino Acid Sequences Common to Rapidly Degraded Proteins; The PEST Hypothesis,” Science (1986) 23(4774):364-368.

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