Sensing phage-triggered ion cascade (SEPTIC)

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

Reexamination Certificate

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C435S287100

Reexamination Certificate

active

11286621

ABSTRACT:
The present invention provides a method for detecting bacteria and a nano-well device having one or more input/output connections about a gap and one or more bacteriophages at or about the gap that trigger a detectable electrical field fluctuation when the one or more bacteriophages contact a cognate target within a liquid sample.

REFERENCES:
patent: 6210910 (2001-04-01), Walt et al.
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Grahn et al. “The Small Viral Membrane-Associated Protein P32 Is Involved in Bacteriophage PRD1 DNA Entry” Journal of Virology, vol. 76, No. 10 (May 2002), p. 4866-4872.
Labedan et al. “Membrane potential changes during the first steps of coliphage infection” Proc. Nat. Acad. Sci. USA, vol. 78, No. 1 (Jan. 1981), pp. 215-219.
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Dwyer, T., Collaboration and modeling solutions integrate with new tools to bolster developer productivity,Yankee Group, Sep. 2005, available at http://developers.sun.com/prodtech/javatools/jsenterprise/reference/whitepapers/YankeeGroup.pdf.
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Venolia, G., Bridges between silos: A Microsoft research project, Microsoft Research Software Improvement Group, Jan. 2005.
PCT International Search Report for PCT/US05/42832 dated Jun. 27, 2006.

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