Sensing chip

Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Structured visual or optical indicator – per se

Reexamination Certificate

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Reexamination Certificate

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08048385

ABSTRACT:
There is provided a sensing chip capable of measuring a refractive index by utilizing a long-range surface plasmon polariton, accurately measuring an accumulative refractive index in a wide range, and more easily enabling sealing for measurement. The present invention relates to the sensing chip which has a thin metal film or a strip-like metal grown on an underlayer, and has a dielectric that limits a refractive index and a dielectric buffer layer on an upper surface and a lower surface of the thin metal film or the strip-like metal. The dielectric buffer layer is attached onto the thin metal film or the strip-like metal. The thin metal film or the strip-like metal and the buffer layer are sandwiched between two dielectric layers. A hole is made in a surface of the upper dielectric layer to serve as a measurement groove.

REFERENCES:
patent: 7671996 (2010-03-01), Niwa et al.
patent: 2006/0274314 (2006-12-01), Thompsen et al.
patent: 2009/0066962 (2009-03-01), Niwa et al.
patent: 2009/0209028 (2009-08-01), Dong et al.
patent: 2003-042944 (2003-02-01), None
patent: 2003-279476 (2003-10-01), None
patent: 2006-250668 (2006-09-01), None
K. Kuhira et al., “Theoretical understanding of an absorption-based surface plasmon resonance sensor based on Kretchmann's theory.”, Anal. Chem. 74(3):696-701 (2002).
Shumaker-Parry J.S. et al., “Microspotting streptavidin and double-stranded DNA arrays on gold for high-throughput studies of protein-DNA interactions by surface plasmon resonance microscopy”, Anal. Chem., 76(4):918-929 (2004).

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