Senna dosage form

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 25, 514892, 536 41, 536 181, 4241951, A61K 3170, A61K 3578

Patent

active

055146635

ABSTRACT:
This invention relates to a pharmaceutical laxative composition in unit dosage form, for peroral administration of sennosides to a human or other animal subject, comprising a safe and effective amount of sennosides in a rapidly dissolving matrix; and a proximal colonic delivery carrier which effects release of said sennosides substantially near the junction between the small intestine and the colon or within the colon of said subject. This invention also involves methods for providing laxation for humans and other animals in need thereof by peroral administration of such compositions.

REFERENCES:
patent: 4432966 (1984-02-01), Zeitoun et al.
patent: 4511561 (1985-04-01), Madaus et al.
patent: 4595592 (1986-06-01), Hietala
patent: 4687667 (1987-08-01), Rhodes et al.
patent: 4801458 (1989-06-01), Hidaka et al.
patent: 4950689 (1990-08-01), Yang et al.
patent: 4990340 (1991-02-01), Hidaka et al.
patent: 5096714 (1992-03-01), Kuhrts
patent: 5108758 (1992-04-01), Allwood et al.
patent: 5178866 (1993-01-01), Wright et al.
patent: 5232699 (1993-08-01), Colliopoulos
patent: 5292518 (1994-03-01), Kuhrts
patent: 5294448 (1994-03-01), Ring et al.
Dreessen, M., H. Eyssen and J. Lemli "The Metabolism of Sennosides A and B by the Intestinal Microflora: in Vitro and In Vivo Studies on the Rat and the Mouse" J. Pharm. Pharmacol., vol. 33 (Apr. 16, 1981), pp. 679-681.
Fioramonti, J., G. Staumont, R. Garcia-Villar, L. Bueno "Effect of Sennosides on Colon Motility in Dogs" Pharmacology, vol. 36 (1988), suppl. 1, pp. 23-30.
Frexinos, J., G. Staumont, J. Fioramonti, and L. Bueno "Effects of Sennosides on Colonic Myoelectrical Activity in Man" Digestive Diseases and Science, vol. 34, No. 2 (Feb. 1989), pp. 214-219.
Garcia-Villar, R., E. Leng-Peschlow, and Y. Ruckebusch "Effect of Anthraquinone Derivatives on Canine and rat intestinal Motility" Pharm. Pharmacol. vol. 32 (1980), pp. 323-329.
Hardcastle, J. D. and J. L. Wilkins "The Action of Sennosides and Related Compounds on Human Colon and Rectum" Gut., vol. 11 (Dec. 1970), pp. 1038-1042.
Lemli, J. and Lemmens "Metabolism of Sennosides and Rhein in the Rat" Pharmacology, vol. 20, (Suppl. 1) (1980), pp. 50-57.
Leng-Peschlow, E. "Acceleration of Large Intestine Transit Time in Rats by Sennosides and Related Compounds" J. Pharm. Pharmacol., vol. 38 (1986), pp. 369-373.
Leng-Peschlow, E. "Dual Effect of Orally Administered Sennosides on Large Intestine Transit and Fluid Absorption in the Rat" J. Pharm. Pharmacol., vol. 38 (1986), pp. 606-610.
Leng-Peschlow, E. "Effects of Sennosides A+B and Bisacodyl on Rat Large Intestine" Pharmacology, vol. 38 (1989) pp. 310-318.
Leng-Peschlow, E. "Effect of Sennosides and Related Compounds on Intestinal Transit in the Rat" Pharmacology, vol. 36 (1988) (Suppl. 1), pp. 40-48.
Staumont, G., J. Frexinos, J. Fioramonti and L. Bueno "Sennosides and Human Colonic Motility" Pharmacology, vol. 36 (Suppl. 1) (1988), pp. 49-56.
Wienbeck, M. E. Kortenhaus, M. Wallenfels and M. Karaus "Effect of Sennosides on Colon Motility in Cats" Pharmacology, vol. 36 (Suppl. 1) (1988) pp. 31-39.
Ambrose et al. Br. J. Surg. vol. 70: 428-430, (1983).
Ziegenhagen et al. Gastrointestinal Endoscopy vol. 37 (5): 547-549, (1991).
Iida et al. Gastroenterologia Japonica vol. 27(6): 728-733, (1992).

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