Senescent cell derived inhibitors of DNA synthesis

Details Senescent cell derived inhibitors of DNA synthesis Senescent cell derived inhibitors of DNA synthesis

1995-09-06

1998-11-24

Hutzell, Paula K.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530395, 514 12, C07K 1400, C07K 14475

Patent

active

058408452

ABSTRACT:
An expression vector cDNA library derived from senescent cells has been used to isolate cDNA clones that encode inhibitors of DNA synthesis. Such inhibitors play a role in cellular senescence and aging. Antisense nucleic acids reduce the inhibition of DNA synthesis.

REFERENCES:
patent: 5424400 (1995-06-01), Smith et al.
Xiong, Y. et al., "D Type Cyclins Associate with Multiple Protein Kinases and the DNA Replication and Repair Factor PCNA," Cell 71:505-514 (1992).
Harper, J.W. et al., "The p21 Cdk-Interacting Protein Cip1 is a Potent Inhibitor of G1 Cyclin-Dependent Kinases," Cell 75:805-816 (1993). This protein has the same sequence as SDI-1.
El-Deiry, W.S. et al., "WAF1, A Potent Mediator of p53 Tumor Suppression," Cell 75:817-825 (1993).
Drescher-Lincoln, C.K. et al., "Inhibition of DNA Synthesis in Proliferating Human Diploid Fibroblasts by Fusion with Senescent Cells," Exp. Cell Res. 144:455-462 (1983).
Drescher-Lincoln, C.K. et al., "Inhibition of DNA Synthesis in Senescent-Proliferating Human Cybrids is Mediated by Endogenous Proteins," Exp. Cell Res. 153:208-217 (1984).
Lumpkin, C.K. et al.,"Existence of High Abundace Antiproliferative mRNA's in Senescent Human Diploid Fibroblasts," Science 232:393-395 (1986).
Maier, J.A.M. et al., "Extension of the Life-Span of Human Endothelial Cells by an Interleukin-1.varies. Antisense Oligomer," Science 249:1570-1574 (1981).
Pereira-Smith, O.M. et al., "Genetic Analysis of Infinte Division in Human Cells: Identification of Four Complemtation Groups," Proc Natl. Acad. Sci. (U.S.A.)85:6042-6046 (1988).
Ning, Y. et al., "Genetic Analysis of Indefinite Division in Human Cells: Evidence for a Cell Senescence-Related Gene(s) on Human Chromosome 4," Proc Natl. Acad. Sci. (U.S.A.) 88:5635-5639 (1991).
Smith, J.R. et al., "Negative Growth Control in cellular Senescence," J. Cell Biochem Suppl. (13 part C) 147 (1989).
Spiering, A.L. et al., "DNA Synthesis Inhibitors and their Possible Roles in the Senescence Phenotype," J. Cell Biochem Suppl. (13 part C) 166 (1989).
West, M.D. et al., "Replicative Senescence of Human Skin Fibroblasts Correlates with a Loss of Regulation and Overexpression of Collagenase Activity," Exp. Cell Res. 184:138-147 (1989).
Giordano, T. et al., "Identification of a Highly Abundant cDNA Isolated from Senescent WI-38 Cells," Exp. Cell Res. 185:399-406 (1989).
Sierra, F. et al., "T-Kininogen Gene Expression is Induced during Aging," Molec. Cell. Biol. 9:5610-5616 (1989).
Smith, J.R., "Expression of Antiproliferartive Genes in Senescent Cells," J.A.G.S. 35:804 (1987).
Smith, J.R., "A Hypothesis for in vitro Cellular Senescence Based on the Population Dynamics of Human Diploid Fibroblasts and Somatic Cell Hybrids," In: Monographs in Developmental Biology; Sauer, H.W. (Ed.), S. Karger, New York, N.Y.17:193-207 (1984).
Smith, J.R. et al., "Further Studies on the Genetic and Biochemical Basis of Cellular Senescence," Exper. Gerontol. 24:377-381 (1989).
Spiering, A.L. et al., "A Potent DNA Synthesis Inhibitor Expressed by the Immortal Cell Line SUSM-1," Exper.Cell Res. 179:159-167 (1988).
Pereira-Smith, O.M. et al., "Senescent and Quiescent Cell Inhibitors of DNA Synthesis Membrane-Associated Proteins," Exper. cell Res.160:297-306 1985;.
Spiering, A.L. et al., "Correlation between Complementation Group for Immortality and DNA Synthesis Inhibitors," Exper. Cell Res. 195:541-545 (1991).
Kleinsek, D.A., "Selection of mRNAs Expressed During Cellular Senescence In Vitro," Age 12:55-60 (1989).
Pereira-Smith, O.M. et al., "Negative Growth Control in Cellular Senescence," J Cell. Biochem. (Suppl 0 (12 part A) 193 (1988).
Kleinsek, D.A. et al., "Isolation of cDNA Sequences Specifics to Senescent Human Diploid Fibroblast Cells In Vitro", Age 10:125 (1987).
Murano, S. et al., "Diverse Gene Sequences Are Overexpressed in Werner Syndrome Fibroblasts Undergoing Premature Replicative Senescence," Molec. Cell. Biol. 11:3905-3914 (Aug. 1991); and.
Takebe, Y. et al., "SR.varies. Promoter: An Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat," Mol. Cell. Biol. 8:466-472 (1988).

Affiliated with

Also associated with

Rating

Senescent cell derived inhibitors of DNA synthesis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Senescent cell derived inhibitors of DNA synthesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Senescent cell derived inhibitors of DNA synthesis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1703480