Senescent cell derived inhibitors of DNA synthesis

Details Senescent cell derived inhibitors of DNA synthesis Senescent cell derived inhibitors of DNA synthesis

1994-01-03

1995-06-13

Draper, Garnette D.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 300, C07K 1500, A01N 3718, A61K 3700

Patent

active

054244005

ABSTRACT:
An expression vector cDNA library derived from senescent cells has been used to isolate cDNA clones that encode inhibitors of DNA synthesis. Such inhibitors play a role in cellular senescence and aging. Antisense nucleic acids reduce the inhibition of DNA synthesis.

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