Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...
Reexamination Certificate
2006-01-19
2009-12-29
Nickol, Gary B. (Department: 1648)
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
C424S093100, C435S320100
Reexamination Certificate
active
07638318
ABSTRACT:
The present invention relates to a novel RNApicornavirusthat is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.
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Cheng Cheng
Ganesh Shanthi
Hales Laura M.
Hallenbeck Paul L.
Hay Carl M.
Li Bao Qun
Nickol Gary B.
Norvartis AG
Wilmer Cutler Pickering Hale and Dorr LLP
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