Semisynthetic erythromycin antibiotics

Details Semisynthetic erythromycin antibiotics Semisynthetic erythromycin antibiotics

1986-06-04

1988-05-03

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 74, A61K 3170, C07H 1708

Patent

active

047420499

ABSTRACT:
Semisynthetic antibiotics with improved therapeutic properties made from erythromycin are disclosed. 11,12-Cyclic carbamates of erythromycin, its derivatives, and their salts and esters show superior in vitro antimicrobial activity and reduced hepatotoxicity compared to the parent compounds.

REFERENCES:
Chemical Abstracts 89:44035g, abstracting an article from the Polish Journal of Chemistry, 52(2), 315-319, (1978).
Chemical Abstracts 90:152554e, abstracting a Japanese patent publication 78,144,589, dated 12/15/78, based on application 77/59,086, dated 5/21/77.

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