Semisynthetic enzymes: apoproteins from heme proteins as hydrola

Details Semisynthetic enzymes: apoproteins from heme proteins as hydrola Semisynthetic enzymes: apoproteins from heme proteins as hydrola

1986-03-20

1988-08-16

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435140, 435141, 435155, 435160, 435161, 435197, 530385, 530402, C12P 702, C12P 706, C12P 716, C12P 740, C12P 754, C12P 752, C12N 918, C07K 1300

Patent

active

047644648

ABSTRACT:
Proteins having a hydrophobic cavity proximate to which is a residue promoting hydrolysis of functional moieties are effective semisynthetic hydrolases. Heme proteins from which the heme has been removed usually have at least one imidazole residue proximate to the cavity, and thus act as quite effective esterases. Because the size and shape of the cavities of such proteins are capable of broad diversity a wide spectrum of substrates may be hydrolyzed by these semisynthetic enzymes.

REFERENCES:
Gratecos, D. and Fischer, E. H., (1974) Biochem. Biophys. Res. Commun. 58, 960-967.
R. Breslow, Science, 218, 532 (1982).
Cram, J. Am. Chem. Soc., 105, 135 (1983).
Breslow, J. Am. Chem. Soc., 103, 154 (1981).
Klotz, Proc. Natl. Acad. Sci., 68 (2), 263 (1971).

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