Semisynthetic diastereomerically pure N-glycidylanthracyclines,

Details Semisynthetic diastereomerically pure N-glycidylanthracyclines, Semisynthetic diastereomerically pure N-glycidylanthracyclines,

1995-06-05

1997-02-11

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 64, A61K 3700, C07M 1524

Patent

active

056021089

ABSTRACT:
Semisynthetic diastereomerically pure N-glycidylanthracyclines, a process for the stereoselective preparation thereof and the use thereof as cytostatics. The invention relates to anthracyclines having cytostatic activity and the formula I, which are, where appropriate, in the form of a salt with an inorganic or organic acid, ##STR1## in which R.sup.1 is hydrogen or a hydroxyl group,

REFERENCES:
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patent: 4948880 (1990-08-01), Hermentin et al.
J. J. Baldwin, A. W. Raab, K Mensler, B. H. Arison, and D. E. McClure, Synthesis of (R)-and (S)-Epichlorohydrin, J. Orig. Chem, vol. 43, Jun. 30, 1978, pp. 4876-4878.
Yuhsuke Kawakami, Tamio Asai, Kiyoshi Umeyama, and Yuya Yamashita Selectively Deuterated and Optically Active Cyclic Ethers, J. Orig. Chem, vol. 47, Jun. 1, 1981, pp. 3581-3585.
Janice M. Klunder, Soo Y. Ko, and K. Barry Sharpless, Asymmetric Epoxidation of Allyl Alcohol: Efficient Routes to Homochiral .beta.-Adrenergic Blocking Agents, J. Orig. Chem, vol. 51, Apr. 15, 1986, pp. 3710-3712.
R. E. Parker and N. S. Isaacs, Mechanisms Of Epoxide Reactions, Chem Rev. 59, Apr. 17, 1959, pp. 737, 799.

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