Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;...
Patent
1993-09-23
1995-10-31
Naff, David M.
Chemistry: molecular biology and microbiology
Carrier-bound or immobilized enzyme or microbial cell;...
435178, 435180, 435182, 43524022, 424451, 4284022, C12N 1100, C12N 1116, C12N 1118
Patent
active
054628660
ABSTRACT:
Microspheres of a substantially uniform diameter are produced having a central portion composed of a solution of a polyanion containing a biological material, and an outer permeable membrane enclosing the central portion which is a complex of the polyanion and a polycation. The biological material has a molecular size greater than 150,000 Daltons, and the membrane has a porosity such that the biological material does not permeate the membrane. The biological material may comprise living cells or living tissue. The microspheres are formed by individually enveloping falling droplets of a polyanion solution with a collapsing annular sheet of a polycation solution while the sheet is traveling downwardly at the same velocity as the droplets.
REFERENCES:
patent: 4279632 (1981-07-01), Frosch et al.
patent: 4324683 (1982-04-01), Lim et al.
patent: 4344787 (1982-08-01), Wang et al.
patent: 4352883 (1982-10-01), Lim
patent: 4391909 (1983-07-01), Lim
patent: 4643854 (1987-02-01), Kendall, Jr. et al.
patent: 4673566 (1987-06-01), Goosen et al.
patent: 4689293 (1987-08-01), Goosen et al.
patent: 4743545 (1988-05-01), Torobin
patent: 4749620 (1988-06-01), Rha et al.
patent: 4806355 (1989-02-01), Goosen et al.
patent: 4806357 (1989-02-01), Garretl et al.
patent: 4956128 (1990-09-01), Hommel et al.
patent: 4960351 (1990-10-01), Kendall, Jr. et al.
patent: 4996150 (1991-02-01), Joung et al.
patent: 5260002 (1993-11-01), Wang
H. Gharapetian et al. "Encapsulation of Viable Cells Within Polyacrylate Membranes", Biotech. and Bioeng., vol. 28, pp. 1595-1600 (1986).
Mattheus F. A. Goosen et al. "Optimization of Microencapsulation Parameters: Semipermeable Microcapsules as a Bioartificial Pancreas", Biotech. and Bioeng., vol. 27, pp. 146-150 (1985).
Hiroo Iwata et al. "Evaluation of Microencapsulated Islets in Agarose Gel as Bioartificial Pancreas by Studies of Hormone Secretion in Culture and by Xenotransplantation", Diabetes vol. 38, Suppl. 1, pp. 224-225 (Jan. 1989).
Ales Prokop "An integration of cultivation and purification in membrane bioreactors: production of monoclonal antibodies and lymphokines by microencapsulated hybridomas", Mol. Biother., vol. 1. No. 2 (1988).
Patrick Soon-Shiong "Successful Long-Term Exocrine and Endocrine Function of the Autotransplanted Pancreas in Humans", Pancreas, vol. 2. No. 3, pp. 357-361 (1987).
Anthony Sun et al. "An Artificial Endocrine Pancreas Containing Cultured Islets of Langerhans", Artificial Endocrine Pancreas, vol. 4, No. 4, pp. 275-278 (Nov. 1980).
P. D. Esser et al. "Dynamics of Vertical Annular Liquid Jets," Journal of Fluids Engineering, Mar. 1984, vol. 106, pp. 45-51.
Wilbert M. Fritschy et al. "Effect of Alginate-Polylysine-Alginate Microencapsulation on In Vitro Insulin Release From Rat Pancreatic Islets," Diabetes, vol. 40, Jan. 1991, pp. 37-43.
M. A. Hoffman et al. "Annular Liquid Jet Experiments," Transactions of the ASME, vol. 102, Sep. 1980, pp. 344-349.
James M. Kendall "Experiments on annular liquid jet instability and on the formation of liquid shells," Phys. Fluids, vol. 29, No. 7, Jul. 1986, pp. 2086-2094.
J. M. Kendall et al. "Metal shell technology based upon hollow jet instability," J.Vac.Sci.Technol., vol. 20, No. 4, Apr. 1982, pp. 1091-1093.
J. M. Kendall et al. "Fluid- and Chemical-Dynamics Relating To Encapsulation Technology," Drops and Bubbles, American Institute of Physics, AIP Conference Proceedings 197, pp. 487-495.
Horace Lamb "Hydrodynamics," Table Of Contents, 1930.
C. P. Lee et al. "A theoretical model for the annular jet instability", Phys. Fluids, vol. 29, No. 7, Jul. 1986, pp. 2076-2085.
Franklin Lim "Biomedical Applications of Microencapsulation", 1984.
Franklin Lim et al. "Microencapsulated Islets as Bioartificial Endocrine Pancreas," Science, vol. 210, Nov. 21, 1980, pp. 908-910.
M. C. Lee et al. "Sensational Spherical Shells," Aerospace America, Jan. 1986, pp. 72-76.
Gregory F. Klomp et al. "Macroporous hydrogel membranes for a hybrid artificial pancreas. II. Biocompatibility," Journal of Biomedical Materials Research, vol. 17, pp. 865-871, 1983.
G. M. O'Shea et al. "Encapsulation of Rat Islets of Langerhans Prolongs Xenograft Survival in Diabetic Mice," Diabetes, vol. 35, Aug. 1986, pp. 943-946.
John W. Pollard et al. "Culture of Rabbit Embryos and Isolated Blastomeres in Hydrogel Chambers Implanted in the Peritoneal Cavity of Intermediate Mouse Recipients," Journal of in Vitro Fertilization and Embryo Transfer, vol. 5, No. 4, 1988, pp. 207-215.
Samuel H. Ronel et al. "Macroporous hydrogel membranes for a hybrid artificial pancreas. I. Synthesis and chamber fabrication," Journal of Biomedical Materials Research, vol. 17, pp. 855-864, 1983.
Camillo Ricordi et al. "A Method for the Mass Isolation of Islets From the Adult Pig Pancreas," Diabetes, vol. 35, Jun. 1986, pp. 649-653.
Camillo Ricordi et al. "Automated Islet Isolation From Human Pancreas," Diabetes, vol. 38, Suppl. 1, Jan. 1989, pp. 140-142.
A. M. Sun et al. "Microencapsulation of Living Cells--A Long-Term Delivery System," Journal of Controlled Release, vol. 2, 1985, pp. 137-141.
Elizabeth G. Posillico "Microencapsulation Technology For Large-Scale Antibody Production," Bio/Technology, vol. 4, Feb. 1986, pp. 114-117.
John C. Shen "Comparative in Vitro and in Vivo Studies of Microencapsulated and Non-encapsulated Adrenocortical Cells," Agriculture, Animal Culture and Nutrition, Dissertation Abstracts International, vol. 45, No. 4, Oct. 1984, p. 1072-B.
Naff David M.
Vanderbilt University
Ware Deborah K.
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