Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-02-01
2005-02-01
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S254080, C514S218000, C514S316000, C514S322000, C514S365000, C540S575000, C544S359000, C544S360000, C544S364000, C544S371000, C546S186000, C546S199000, C548S181000
Reexamination Certificate
active
06849631
ABSTRACT:
The present invention relates to the synthesis of a new class of indeno [1,2-c]pyrazol-4-ones of formula (I):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
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Bristol - Myers Squibb Pharma Company
Kifle Bruck
Korsen Elliott
Patel Rena
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