Semi-synthetic taxanes with anti-tumoural activity

Details Semi-synthetic taxanes with anti-tumoural activity Semi-synthetic taxanes with anti-tumoural activity

1995-07-24

1998-05-26

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549511, 514449, C07D30514

Patent

active

057567760

ABSTRACT:
The present invention relates to novel derivatives obtained by oxidation and the stereospecific reduction of 10-deacetylbaccatine III, and successive esterification with a variously substituted isoserine chain to prepare taxol analogues. The products of the invention have cytotoxic and anti-tumoural activities and, when suitably formulated, can be administered by injection and/or orally.

REFERENCES:
patent: 5200534 (1993-04-01), Rao
patent: 5399726 (1995-03-01), Holton et al.
patent: 5608102 (1997-03-01), Bourzat
E. Didier et al., "Expeditious Semisynthesis of Docetaxel Using 2-Trichloromethyl-1,3-Oxazolidine as Side-Chain Protection," Tetrahedron Letters, vol. 35, No. 19 (1994), pp. 3063-3064.
E. Didier et al., "2-Monosubstituted-1,3-Oxazolidines as Improved Protective Groups of N-Boc-Phenylisoserine in Docetaxel Preparation," Tetrahedron Letters, vol. 35, No. 15 (1994) pp. 2349-2352.
Denis et al, J. Am. Chem. Soc., 110 (17), pp. 5917-5919, 1988.

Affiliated with

Also associated with

Rating

Semi-synthetic taxanes with anti-tumoural activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Semi-synthetic taxanes with anti-tumoural activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Semi-synthetic taxanes with anti-tumoural activity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1962309