Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2008-05-06
2008-05-06
Kosar, Andrew D. (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S009100, C514S023000, C530S317000, C530S322000
Reexamination Certificate
active
07368422
ABSTRACT:
Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.
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Bai Yu
Chu Daniel
Lei Yaohui
Ni Zhi-Jie
Wang John Jian-Xin
Beyer & Weaver, LLP
Kosar Andrew D.
Novartis Vaccines and Diagnostics Inc.
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