Semi-synthetic conversion of paclitaxel to docetaxel

Details Semi-synthetic conversion of paclitaxel to docetaxel Semi-synthetic conversion of paclitaxel to docetaxel

2011-03-15

2011-03-15

Andres, Janet L. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S511000

Reexamination Certificate

active

07906661

ABSTRACT:
A process is provided for the semi-synthesis of taxane derivatives useful in the preparation of docetaxel, in particular, the semi-synthesis of protected taxane derivatives in a one pot reaction of protecting the C-2′, C-7 and C-10 positions and introducing a t-Boc group at the nitrogen of the amide group at the C-3′ position in paclitaxel and subsequently conversion to docetaxel, and derivatives used therein.

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