Semi-synthesis of human insulin

Details Semi-synthesis of human insulin Semi-synthesis of human insulin

1981-12-31

1983-08-23

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

435896, 435886, 435824, C12P 2104, C12R 1025, C12R 1465, C12R 154

Patent

active

044004656

ABSTRACT:
A process for preparing a B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on the basic-amino-acid carbonyl in peptide bondings.

REFERENCES:
patent: 3276961 (1966-10-01), Bodanszky et al.
patent: 3903068 (1975-02-01), Ruttenberg
patent: 4320196 (1982-03-01), Morihara et al.
Yoshida et al., FEBS Letters, 15(2), 129-132, (1971).
Schmitt et al., Hoppe-Seyler's Z. Physiol. Chem., 359, 799-802, (1978).
Obermeier et al., Hoppe-Seyler's Z. Physiol. Chem., 357, 759-767, (1976).
Inouye et al., JACS, 101, 751-752, (1979).
Morihara et al., Nature, 280, 412-413, (1979).
Morihara et al., Arch. Biochem. Biophys., 126, 971-973, (1968).

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