Semi-synthesis of human insulin

Details Semi-synthesis of human insulin Semi-synthesis of human insulin

1980-04-09

1982-03-16

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

435824, 424178, C12P 2106

Patent

active

043201970

ABSTRACT:
A process for preparing a B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on a lysine carbonyl in peptide bondings and produced by Achromobacter lyticus M 497-1.

REFERENCES:
patent: 3276961 (1966-10-01), Bodanszky et al.
patent: 3649454 (1972-03-01), Isono et al.
patent: 3903068 (1975-09-01), Ruttenberg
patent: 3903069 (1975-09-01), Gregory et al.
Masaki et al. Agric. Biol. Chem., 42(7), 1443-1445 (1978).
Morihara et al., Biochem. Biophys. Res. Commun., 92(2), 396-402, (1980).
Schmitt et al., Hoppe-Seyler's Z. Physiol. Chem., 359, 799-802 (1978).
Obermeier et al., Hoppe-Seyler's Z. Physiol. Chem., 357, 759-767 (1976).

Affiliated with

Also associated with

Rating

Semi-synthesis of human insulin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Semi-synthesis of human insulin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Semi-synthesis of human insulin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1642373