Semi-synthesis of human insulin

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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C07C10352

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045115052

ABSTRACT:
A process for preparing a B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on the basic-amino-acid carbonyl in peptide bondings.

REFERENCES:
patent: 3276961 (1966-10-01), Bodanszky et al.
patent: 3950517 (1976-04-01), Lindsay et al.
patent: 4029642 (1977-06-01), Obermeir
Science, vol. 177, 623-626-Ruttenberg.

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