Semi-synthesis of human insulin

Details Semi-synthesis of human insulin Semi-synthesis of human insulin

1981-12-31

1983-08-30

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

435824, C12P 2104, C12R 1025

Patent

active

044017570

ABSTRACT:
A process for preparing B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on a lysine carbonyl in peptide bondings and produced by Achromobacter lyticus M 497-1.

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patent: 3903068 (1975-09-01), Ruttenberg
patent: 3903069 (1975-09-01), Gregory et al.
patent: 4320197 (1982-03-01), Morihara et al.
Masaki et al., Agr. Biol. Chem., 42(7) 1443-1445 (1978).
Morihara et al., Biochem. Biophys. Res. Commun., 92(2), 396-402 (1980).
Schmitt et al., Hoppe-Seyler's Physiol. Chem., 359, 799-802 (1978).
Obermeier et al., Hoppe-Seyler's Z. Physiol. Chem. 357, 759-767 (1976).

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