Semi-automatic, solid-phase peptide multi-synthesizer and proces

Details Semi-automatic, solid-phase peptide multi-synthesizer and proces Semi-automatic, solid-phase peptide multi-synthesizer and proces

1986-05-27

1988-05-31

Phillips, Delbert R.

Chemical apparatus and process disinfecting, deodorizing, preser

Control element responsive to a sensed operating condition

Sensed condition is operating time and control is operation...

422131, 530333, 530334, 525 5411, C07K 104, C07K 106, C07K 110, B01J 802

Patent

active

047480025

ABSTRACT:
A semi-automatic, solid phase peptide multi-synthesizer is characterized in that it is principally constituted by chemical reactors (2), connected to volumetric solvent proportioners (1) disposed above the said chemical reactors (2) and below a solvent selector (4) supplied with solvent by solvent containers (6) under pressure of nitrogen distribution cylinders (3), as well as a center for adjustment and regulation of very low pressure nitrogen (5), are sequentially controlled by a programmable automation (7) or a microcomputer assuring the carrying out of the synthesis technique. The maximum number of volumetric solvent proportioner (1)--chemical reactor (2) assemblies is equal to the maximum number of peptides which may be produced simultaneously.

REFERENCES:
patent: 3557077 (1971-01-01), Brunfeldt et al.
patent: 3715190 (1973-02-01), Park et al.
patent: 4517338 (1985-05-01), Urdea et al.
patent: 4552922 (1985-11-01), Patchormik et al.
patent: 4598049 (1986-07-01), Zelinka et al.
"An Automatic Apparatus for the Synthesis of Peptides Using Resin Coated Glass Beads in the Form of a Packed Bed", Journal of Chromatographic Science, vol. 10, Jun. 1972, by R. P. W. Scott et al., pp. 384-391.

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