Refrigeration – Storage of solidified or liquified gas – Including cryostat
Patent
1995-02-08
1996-07-09
Kilner, Christopher
Refrigeration
Storage of solidified or liquified gas
Including cryostat
62320, 839155, F25B 1900, F25C 502, G01N 106, B26D 708
Patent
active
055333427
ABSTRACT:
The present invention provides a system and method for freezing and cutting a tissue specimen for medical diagnostic purposes which comprises a specimen block holder for holding the tissue specimen; an embedding medium; a freezing plane for providing direct metal contact freezing of the specimen; a knife blade comprising a cutting edge which is substantially parallel to and may be displaced a preset distance from the freezing plane; a block holder for holding the specimen; and driving means for transporting the block holder towards the freezing plane for creating a flat frozen surface of the specimen having a thickness t and also for transporting the frozen specimen past the knife edge to provide a section having a desired thickness. The planar relationship and known distance between the freezing plane and the cutting edge together will be used as the basis for calculating frozen thickness t of the specimen. This allows for precise and automated movement of the block holder for trimming. The freezing plane is preferably cooled by means of first and second refrigerants which are capable of being stored in a single compressor. The use of two mating wedge washers are preferably provided at the freezing block to insure a proper parallel orientation between the cutting edge and the freezing plane.
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Cryostar.RTM.-95.degree. C Ultra-Low Temperature Freezers.
Kilner Christopher
Mugno John R.
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