Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-09-24
2000-04-25
Kemmerer, Elizabeth
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 231, 536 2431, 4353201, 435325, 4352523, 4351723, 530300, 530350, C07H 2104, C12N 1512, C12N 1563
Patent
active
060542934
ABSTRACT:
The invention provides methods and compositions relating to two classes of semaphorin receptors, SR1 and SR2. The polypeptides may be produced recombinantly from transformed host cells from the disclosed SR encoding nucleic acids or purified from human cells. The invention provides isolated SR hybridization probes and primers capable of specifically hybridizing with the disclosed SR genes, SR-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
REFERENCES:
Watson J.D. et al., Molecular Biology of the Gene, Fourth Edition, The Benjamin/Cummings Publishing Company, Inc., p. 313, 1987.
Kawakami A. et al., Developmentally regulated Expression of a Cell Surface Protein, Neuropilin, in Mouse Nervous System, Journal of Neurobiology, vol. 29, No. 1, pp. 1-17, Jan. 1, 1996.
He. Z. et al., Neuropilin is a Receptor for the Axonal Chemorepellent Semaphorin II. Cell, vol. 90, pp. 739-751, 1997.
Kolodkin A. et al., Neuropilin is a Semaphorin III Receptor, Cell, vol. 90, pp. 753-762, 1997.
Takagi S. et al., Expression of a Cell Adhesion Molecule, Neuropilin, in the Developing Chick Nervous system, Developmental Biology, vol. 170, pp. 207-222, 1995.
Takagi S. et al., The A5 Antigen, a candidate for the Neuronal Recognition Molecole, has Homologies to Complement Components and Coagulation Factors, Neuron, vol. 7, pp. 295-307, 1991.
Chen, H. et al., Neuropilin-2, a Novel member of the Neuropilin family, Is a high affinity receptor for thr Semaphorins Sema E and Sema IV but not Sema III, Neuron, vol. 19, pp. 547-559, Sep., 1997.
Chen Hang
He Zhigang
Tessier-Lavigne Marc
Basi Nirmal S.
Kemmerer Elizabeth
Osman Richard Aron
The Regents of the University of California
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