Semaphorin gene family

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 235, C07H 2104, C12N 1511

Patent

active

060137819

ABSTRACT:
A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.

REFERENCES:
Waterson et al., Nature Genetics 1(2): 114-123, May 1992.
Kolodkin et al. Neuron, 9:831-845, 1992.
Genbank Accession No. M61187.
Genbank Accession No. X57318.
Genbank Acession No. M35707.
Genbank Accession No. X62984 (Harbitz et al.).

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