Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-04-08
2000-01-11
Duffy, Patricia A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 235, C07H 2104, C12N 1511
Patent
active
060137819
ABSTRACT:
A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.
REFERENCES:
Waterson et al., Nature Genetics 1(2): 114-123, May 1992.
Kolodkin et al. Neuron, 9:831-845, 1992.
Genbank Accession No. M61187.
Genbank Accession No. X57318.
Genbank Acession No. M35707.
Genbank Accession No. X62984 (Harbitz et al.).
Bentley David R.
Goodman Corey S.
Kolodkin Alex L.
Matthes David
O'Connor Timothy
Duffy Patricia A.
Osman Richard Aron
The Regents of the University of California
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