Self-toxification process for aerobic fermentation

Details Self-toxification process for aerobic fermentation Self-toxification process for aerobic fermentation

1977-08-25

1979-10-02

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

435813, C12B 108, C12B 120

Patent

active

041697626

ABSTRACT:
During the aerobic fermentation process, when it is desired to kill the microorganism, a growth essential material such as the carbon source or the oxygen source is interrupted for a period of time sufficient to lower the concentration of the material to a level at which the microorganism substantially ceases to propagate. After this concentration has been reached, flow of the material is then rapidly reestablished in a quantity so that the concentration of the material in the fermentation medium is such that the microorganism will generate a toxic amount of formaldehyde and thereby kill the microorganism.

REFERENCES:
patent: 3616224 (1971-10-01), Shilo et al.
patent: 3764476 (1973-10-01), Abe et al.
patent: 3834989 (1975-09-01), Harrison
Anthony et al., "The Microbial Oxidation of Methanol", Biochem. J., vol. 92, pp. 609-614 (1964).
Ogata et al., "A Yeast Capable of Utilizing Methanol", Agr. Biol. Chem., vol. 33, No. 10, pp. 1519-1520 (1969).
Levine et al., "Isolation and Characterization of a Thermotolerant Methanol-Utilizing Yeast", Applied Microbiology, vol. 26, No. 6, pp. 982-990 (1973).
Cook, The Chemistry and Biology of Yeasts, Academic Press, Inc., New York, (1958), pp. 256-275.

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