Optical waveguides – Optical waveguide sensor
Reexamination Certificate
2007-04-10
2007-04-10
Font, Frank G. (Department: 2883)
Optical waveguides
Optical waveguide sensor
C385S037000, C385S129000, C356S246000, C422S051000, C422S082110, C422S105000, C435S007100
Reexamination Certificate
active
10947021
ABSTRACT:
Self-referencing optical sensors and methods are described herein that can be used to detect bio-chemical interactions (e.g., biological binding of antigen-antibody pairs) that occur in for example a microplate. In one embodiment, the self-referencing optical sensor includes a substrate, a lower (reference) waveguide grating structure, a buffer layer and an upper (sensing) waveguide grating structure. This self-referencing optical sensor enables an optical interrogation system to detect a bio-chemical interaction independent of the effect of temperature by measuring a reference signal associated with the lower (reference) waveguide grating structure and measuring a sensing signal associated with the upper (sensing) waveguide grating structure. These two signals are then subtracted from one another to determine a sensing measurement that represents whether or not the bio-chemical interaction occurred that is independent of the effect of temperature. This is all possible because the self-referencing optical sensor has a lower (reference) waveguide grating structure with a thickness that was sized to make a rate of change of a lower resonant wavelength/temperature variation (ΔλL/ΔT) substantially equal to a rate of change of an upper resonant wavelength/temperature variation (ΔλU/ΔT). Several other embodiments of self-referencing optical sensors which have a specific structures and/or a specific compositions are also described herein.
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Krol Mark F.
Salik Mark D.
Beall Thomas R.
Corning Incorporated
Font Frank G.
Mooney Michael P.
Tucker William J.
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