Self-referencing spectrophotometric measurements

Chemistry: analytical and immunological testing – Optical result – Spectrum analysis

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356326, 422 8208, 422 8209, 422 8211, 436178, G01N 2100

Patent

active

052984281

ABSTRACT:
A method for measuring the concentration of a chemical substance by spectrophotometry comprising the steps of placing a sample of a photoreactive substance between the light source and a spectrophotometer, obtaining an absorption spectrum of the substance using a fixed amount of light from the light source, obtaining a second absorption spectrum after a short interval, comparing the two to determine the concentration of the chemical substance from the difference in the spectra. If the chemical substance is not photoreactive, a photoreactive mixture can be made with a photoreactive dye that has photoreactive properties unique to the mixture. Alternatively, an optically transparent substrate can absorb the substance or the dye/substance mixture.

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Stephen Brewer, "Solving Problems In Analytical Chemistry", 1980, pp. 268-285.
John W. Moore, Ralph G. Pearson, Kinetics and Mechanism, 1981, pp. 421-422.

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