Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Reexamination Certificate
2006-03-07
2008-12-23
Weber, Jon P (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
Reexamination Certificate
active
07468258
ABSTRACT:
The inventive subject matter relates to methods, kits, and compositions for detecting enzyme activity in a biological sample. In particular, the inventive subject matter relates to methods, kits, and compositions for detecting von Willebrand factor degrading enzyme activity in a biological sample.
REFERENCES:
patent: 2007/0065895 (2007-03-01), Miyata et al.
Kokame et al. British Journal of Haematology 2005;129:93-100.
Zhang Biochem & Biophy Res Communication 2004, 323:674-678.
Zanardelli, et al., ADAMTS13 substrate recognition of von Willebrand factor A2 domain. J Biol Chem. Jan. 20, 2006;281(3):1555-63. Epub Oct. 12, 2005.
Sutherland, et al., Molecular modeling of the von Willebrand factor A2 Domain and the effects of associated type 2A von Willebrand disease mutations. J Mol. Model. Aug. 2004;10(4):259-70. Epub Aug. 3, 2004.
Hassenpflug, et al., Impact of mutations in the von Willebrand factor A2 domain on ADAMTS13-dependent proteolysis. Blood. Mar. 15, 2006;107(6):2339-45. Epub Dec. 1, 2005.
Kokame, et al., VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13. Blood. Jan. 15, 2004;103(2):607-12. Epub Sep. 25, 2003.
Jenkins, et al., Molecular modeling of ligand and mutation sites of the type A domains of human von Willebrand factor and their relevance to von Willebrand's disease. Blood. Mar. 15, 1998;91(6):2032-44.
Dong, et al., ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor. J Biol Chem. Aug. 8, 2003;278(32):29633-9. Epub May 29, 2003.
Anderson, et al., Zinc and calcium ions cooperatively modulate ADAMTS13 activity. J Biol Chem. Jan. 13, 2006;281(2):850-7. Epub Nov. 11, 2005.
Majerus, et al., Binding of ADAMTS13 to von Willebrand factor. J Biol Chem. Jun. 10, 2005;280(23):21773-8. Epub Apr. 11, 2005.
Sheffield University VWF Information Homepage, including links to von Willebrand Factor mutations and polymorphisms associated with von Willebrand Diseases; Type 2A mutations: see http://www.ragtimedesign.com/vwf/mutation/mutationtableresults.php; Type 2A polymorphisms: http://www.ragtimedesign.com/vwf/polymorphism/polytableresults.php.
Heiman Lee C.
Nath Gary M.
Shen Bin
The Nath Law Group
Wake Forest University Health Sciences
LandOfFree
Self-quenching homofluorophore compositions for detecting... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Self-quenching homofluorophore compositions for detecting..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Self-quenching homofluorophore compositions for detecting... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4050837