Self-gelling therapeutic compositions for topical application

Details Self-gelling therapeutic compositions for topical application Self-gelling therapeutic compositions for topical application

1984-06-06

1986-01-07

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

424 52, A61K 3316

Patent

active

045633517

ABSTRACT:
A self-gelling aqueous therapeutic composition for topical application and for the sustained release of a medicant compound, which compositions comprise an aqueous ethyl orthosilicate emulsion, a therapeutic compound which is to be released in a sustained manner on topical application, a gelling facilitating agent to aid the in situ gelation of the ethyl orthosilicate composition comprising a surface-active agent and/or a low concentration of an ammonium or fluoride compound and a gelling accelerating compound to accelerate the conversion of the solution to a gel state, which accelerator compound comprises an imidazole compound to effect the self gelling of the composition.

REFERENCES:
patent: 4411889 (1983-10-01), Caslavsky et al.

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