Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is particulate and the particles are of...
Reexamination Certificate
2010-07-12
2011-10-04
Gabel, Gail R (Department: 1641)
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is particulate and the particles are of...
C435S006120, C435S007100, C435S287200, C435S288400, C436S010000, C436S164000, C436S171000, C436S172000, C436S518000, C422S082050, C422S082060, C422S082070, C422S082080, C422S091000
Reexamination Certificate
active
08030094
ABSTRACT:
A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.
REFERENCES:
patent: 4200110 (1980-04-01), Peterson et al.
patent: 4499052 (1985-02-01), Fulwyler
patent: 4682895 (1987-07-01), Costello
patent: 4785814 (1988-11-01), Kane
patent: 4822746 (1989-04-01), Walt
patent: 4824789 (1989-04-01), Yafuso et al.
patent: 4999306 (1991-03-01), Yafuso et al.
patent: 5002867 (1991-03-01), Macevicz
patent: 5028545 (1991-07-01), Soini
patent: 5105305 (1992-04-01), Betzig et al.
patent: 5114864 (1992-05-01), Walt
patent: 5132242 (1992-07-01), Cheung
patent: 5143853 (1992-09-01), Walt
patent: 5194300 (1993-03-01), Cheung
patent: 5244636 (1993-09-01), Walt et al.
patent: 5244813 (1993-09-01), Walt et al.
patent: 5250264 (1993-10-01), Walt et al.
patent: 5252494 (1993-10-01), Walt
patent: 5254477 (1993-10-01), Walt
patent: 5298741 (1994-03-01), Walt et al.
patent: 5302509 (1994-04-01), Cheeseman
patent: 5303021 (1994-04-01), Kita
patent: 5308771 (1994-05-01), Zhou et al.
patent: 5320814 (1994-06-01), Walt et al.
patent: 5357590 (1994-10-01), Auracher
patent: 5380489 (1995-01-01), Sutton et al.
patent: 5435724 (1995-07-01), Goodman et al.
patent: 5474895 (1995-12-01), Ishii et al.
patent: 5481629 (1996-01-01), Tabuchi
patent: 5494798 (1996-02-01), Gerdt et al.
patent: 5494810 (1996-02-01), Barany et al.
patent: 5496997 (1996-03-01), Pope
patent: 5512490 (1996-04-01), Walt et al.
patent: 5516635 (1996-05-01), Ekins et al.
patent: 5518883 (1996-05-01), Soini
patent: 5565324 (1996-10-01), Still et al.
patent: 5567598 (1996-10-01), Stitt et al.
patent: 5573909 (1996-11-01), Singer et al.
patent: 5575909 (1996-11-01), Foster
patent: 5599668 (1997-02-01), Stimpson et al.
patent: 5633972 (1997-05-01), Walt et al.
patent: 5639603 (1997-06-01), Dower et al.
patent: 5656241 (1997-08-01), Seifert et al.
patent: 5679524 (1997-10-01), Nikiforov et al.
patent: 5690894 (1997-11-01), Pinkel et al.
patent: 5739000 (1998-04-01), Bierre et al.
patent: 5814524 (1998-09-01), Walt et al.
patent: 5830711 (1998-11-01), Barany et al.
patent: 5837196 (1998-11-01), Pinkel et al.
patent: 5840256 (1998-11-01), Demers et al.
patent: 5854684 (1998-12-01), Stabile et al.
patent: 5856083 (1999-01-01), Chelsky et al.
patent: 5858659 (1999-01-01), Sapolsky et al.
patent: 5858732 (1999-01-01), Solomon et al.
patent: 5863708 (1999-01-01), Zanzucchi et al.
patent: 5866331 (1999-02-01), Singer et al.
patent: 5888723 (1999-03-01), Sutton et al.
patent: 5900481 (1999-05-01), Lough et al.
patent: 6013456 (2000-01-01), Akhavan-Tafti
patent: 6023540 (2000-02-01), Walt et al.
patent: 6027889 (2000-02-01), Barany et al.
patent: 6051380 (2000-04-01), Sosnowski et al.
patent: 6054564 (2000-04-01), Barany et al.
patent: 6083763 (2000-07-01), Balch
patent: 6110678 (2000-08-01), Weisburg et al.
patent: 6172218 (2001-01-01), Brenner
patent: 6251639 (2001-06-01), Kurn
patent: 6268148 (2001-07-01), Barany et al.
patent: 6300063 (2001-10-01), Lipshutz
patent: 6309822 (2001-10-01), Fodor et al.
patent: 6344316 (2002-02-01), Lockhart et al.
patent: 6406845 (2002-06-01), Walt et al.
patent: 6468476 (2002-10-01), Friend
patent: 7115884 (2006-10-01), Walt et al.
patent: 7348181 (2008-03-01), Walt et al.
patent: 7754498 (2010-07-01), Walt et al.
patent: 0 269 764 (1988-06-01), None
patent: 0 392 546 (1990-10-01), None
patent: 0 478 319 (1992-04-01), None
patent: 0 723 146 (1996-07-01), None
patent: 2 294 319 (1996-04-01), None
patent: WO 89/11101 (1989-11-01), None
patent: WO 91/02975 (1991-03-01), None
patent: WO 93/02360 (1993-02-01), None
patent: WO 93/22503 (1993-11-01), None
patent: WO 93/25563 (1993-12-01), None
patent: WO 94/03104 (1994-02-01), None
patent: WO 94/12863 (1994-06-01), None
patent: WO 95/06253 (1995-03-01), None
patent: WO 95/11454 (1995-04-01), None
patent: WO 96/03212 (1996-02-01), None
patent: WO 96/28538 (1996-09-01), None
patent: WO 97/12030 (1997-04-01), None
patent: WO 97/14028 (1997-04-01), None
patent: WO 97/14028 (1997-04-01), None
patent: WO 97/14928 (1997-04-01), None
patent: WO 97/31256 (1997-08-01), None
patent: WO 97/31256 (1997-08-01), None
patent: WO 97/40385 (1997-10-01), None
patent: WO 98/13523 (1998-04-01), None
patent: WO 97/40726 (1998-09-01), None
patent: WO 98/40726 (1998-09-01), None
patent: WO 98/50782 (1998-11-01), None
patent: WO 98/50782 (1998-11-01), None
patent: WO 98/53093 (1998-11-01), None
patent: WO 98/53300 (1998-11-01), None
patent: WO 98/53300 (1998-11-01), None
patent: WO 98/53300 (1998-11-01), None
patent: WO 99/18434 (1999-04-01), None
patent: WO 99/54724 (1999-10-01), None
patent: WO 99/60170 (1999-11-01), None
patent: WO 99/60450 (1999-11-01), None
patent: WO 99/67414 (1999-12-01), None
patent: WO 99/67641 (1999-12-01), None
patent: WO 99/67641 (1999-12-01), None
patent: WO 00/04372 (2000-01-01), None
patent: WO 00/13004 (2000-03-01), None
patent: WO 00/16101 (2000-03-01), None
patent: WO 00/16101 (2000-03-01), None
patent: WO 99/13004 (2000-03-01), None
patent: WO 99/13004 (2000-03-01), None
patent: WO 00/18962 (2000-04-01), None
patent: WO 00/34788 (2000-06-01), None
patent: WO 00/39587 (2000-07-01), None
patent: WO 00/47607 (2000-08-01), None
patent: WO 00/47996 (2000-08-01), None
patent: WO 00/47996 (2000-08-01), None
patent: WO 00/48000 (2000-08-01), None
patent: WO 00/58516 (2000-10-01), None
patent: WO 00/58516 (2000-10-01), None
patent: WO 00/60332 (2000-10-01), None
patent: WO 00/63437 (2000-10-01), None
patent: WO 00/63437 (2000-10-01), None
patent: WO 00/71243 (2000-11-01), None
patent: WO 00/71995 (2000-11-01), None
patent: WO 00/71995 (2000-11-01), None
patent: WO 00/75373 (2000-12-01), None
patent: WO 00/75373 (2000-12-01), None
patent: WO 01/46675 (2001-06-01), None
patent: WO 03/02979 (2003-01-01), None
Abel, A., et al. “Fiber-optic evanescent wave biosensor for the detection of oligonucleotides,”Anal. Chem. 68(17):2905-2912 (Sep. 1996).
Anon., “Fluorescent microspheres,”Tech. Notes 19, Bang Laboratories: Fisher, IN (Feb. 1997).
Anon., “Microsphere selection guide,” Bang Laboratories: Fisher, IN (Sep. 1998).
Bangs, L.B., “Immunological applications of microspheres,”The Latex Course, Bang Laboratories: Carmel, IN (Apr. 1996).
Barnard, S.; et al., “A fibre-optic chemical sensor with discrete sensor sites,”Nature353(6342):338-340 (Sep. 1991).
Chen et al., “Ratio-Based Decisions and the Quantitative Analysis of cDNA Microarray Images,”Journal of Biomedical Optics, vol. 2 No. 4, pp. 364-374 (Oct. 1997).
Chen, J., et al., “A microsphere-based assay for multiplexed single nucleotide polymorphism analysis using single base chain extension,”Genome Res. 10(4):549-557 (Apr. 2000).
Czarnik, A. et al., “Illuminating the SNP genomic code,”Modern Drug Disc. 1(2):49-55 (1998).
Drmanac, R., et al., “Prospects for a miniaturized, simplified and frugal human genome project,”Scientia Yugoslavica16(1-2):97-107 (1990).
Drmanac, R., et al., “Sequencing by hybridization (SBH) with oligonucleotide probes as an integral approach for the analysis of complex genomes,”Int. J. Genome Res. 1(1):59-79 (1992).
Drmana
Dickinson Todd A.
Walt David R.
Gabel Gail R
Knobbe Martens Olson & Bear LLP
Trustees of Tufts College
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