Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Reexamination Certificate
2001-03-06
2010-06-15
Tran, S. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
C424S450000, C424S451000
Reexamination Certificate
active
07736666
ABSTRACT:
The present invention claims and discloses a pharmaceutical composition suitable for oral administration, in form of an emulsion pre-concentrate, comprising (i) a compound of formula (I); (ii) one or more surfactants; (iii) optionally an oil or semi-solid fat; said composition forming an in-situ oil-in-water emulsion upon contact with aqueous media such as gastrointestinal fluids. The composition may optionally also comprise one or more short-chain alcohols. The pharmaceutical composition is useful in the treatment of pain and inflammation.
REFERENCES:
patent: 4255431 (1981-03-01), Junggren et al.
patent: 4508905 (1985-04-01), Junggren et al.
patent: 4554276 (1985-11-01), LaMattina
patent: 4562261 (1985-12-01), Hirata et al.
patent: 4619934 (1986-10-01), Sunshine et al.
patent: 4676984 (1987-06-01), Wu et al.
patent: 4704278 (1987-11-01), Wu et al.
patent: 4757060 (1988-07-01), Lukacsko et al.
patent: 4758579 (1988-07-01), Kohl et al.
patent: 4766117 (1988-08-01), Crawford et al.
patent: 4786505 (1988-11-01), Lovgren et al.
patent: 4965065 (1990-10-01), Lukacsko et al.
patent: 5037815 (1991-08-01), Lukacsko et al.
patent: 5043358 (1991-08-01), Lukacsko et al.
patent: 5204118 (1993-04-01), Goldman et al.
patent: 5260333 (1993-11-01), Lukacsko et al.
patent: 5364616 (1994-11-01), Singer et al.
patent: 5373022 (1994-12-01), Fawzi et al.
patent: 5417980 (1995-05-01), Goldman et al.
patent: 5466436 (1995-11-01), Stables
patent: 5514663 (1996-05-01), Mandel
patent: 5631022 (1997-05-01), Mandel et al.
patent: 5643960 (1997-07-01), Breitner et al.
patent: 5686105 (1997-11-01), Kelm et al.
patent: 5716648 (1998-02-01), Halskov et al.
patent: 5929030 (1999-07-01), Hamied et al.
patent: 5932243 (1999-08-01), Fricker et al.
patent: 5955451 (1999-09-01), Lichtenberger et al.
patent: 5965160 (1999-10-01), Benita et al.
patent: 6013281 (2000-01-01), Lundberg et al.
patent: 6025395 (2000-02-01), Breitner et al.
patent: 6054136 (2000-04-01), Farah et al.
patent: 6160020 (2000-12-01), Ohannesian et al.
patent: 6162816 (2000-12-01), Bohlin et al.
patent: 6207188 (2001-03-01), Gustavsson et al.
patent: 6231888 (2001-05-01), Lerner et al.
patent: 6267985 (2001-07-01), Chen et al.
patent: 6312704 (2001-11-01), Farah et al.
patent: 6365184 (2002-04-01), Depui et al.
patent: 6395298 (2002-05-01), Flanagan et al.
patent: 6436430 (2002-08-01), Mulye
patent: 6485747 (2002-11-01), Flanagan et al.
patent: 6544556 (2003-04-01), Chen et al.
patent: 6613354 (2003-09-01), Depui et al.
patent: 6635281 (2003-10-01), Wong et al.
patent: 2001/0025107 (2001-09-01), Barberich et al.
patent: 2001/0036473 (2001-11-01), Scott et al.
patent: 2001/0044410 (2001-11-01), Gelber et al.
patent: 2002/0012676 (2002-01-01), Lundeberg et al.
patent: 2002/0042433 (2002-04-01), Yelle et al.
patent: 2002/0044962 (2002-04-01), Cherukuri et al.
patent: 2002/0045184 (2002-04-01), Chen
patent: 2002/0086029 (2002-07-01), Lundberg et al.
patent: 2002/0111370 (2002-08-01), Bergman et al.
patent: 2002/0155153 (2002-10-01), Depui et al.
patent: 2003/0008903 (2003-01-01), Barberich et al.
patent: 2003/0113375 (2003-06-01), Lundberg et al.
patent: 2003/0129235 (2003-07-01), Chen et al.
patent: 2004/0052824 (2004-03-01), Abou Chacra-Vernet et al.
patent: 4 131 678 (1992-10-01), None
patent: 0 005 129 (1979-10-01), None
patent: 0 166 287 (1986-01-01), None
patent: 0 174 726 (1986-03-01), None
patent: 0 274 870 (1988-07-01), None
patent: 0 274 870 (1988-07-01), None
patent: 0 320 550 (1989-06-01), None
patent: 0 426 479 (1991-05-01), None
patent: 0 426 479 (1991-05-01), None
patent: 0 550 083 (1993-07-01), None
patent: 0 984 012 (2000-03-01), None
patent: 2 105 193 (1983-03-01), None
patent: 2 163 747 (1986-03-01), None
patent: WO 85/03443 (1985-08-01), None
patent: 90/06925 (1990-06-01), None
patent: WO 93/12817 (1993-07-01), None
patent: WO 94/04484 (1994-03-01), None
patent: WO 94/07541 (1994-04-01), None
patent: WO 94/12463 (1994-06-01), None
patent: 94/27988 (1994-12-01), None
patent: 95/01977 (1995-01-01), None
patent: WO 95/08983 (1995-04-01), None
patent: WO 95/09831 (1995-04-01), None
patent: WO 9509831 (1995-04-01), None
patent: WO 95/30641 (1995-11-01), None
patent: 96/01623 (1996-01-01), None
patent: 97/25064 (1997-07-01), None
patent: WO 98/22117 (1998-05-01), None
patent: WO 99/00380 (1999-01-01), None
patent: WO 99/12524 (1999-03-01), None
patent: WO 99/56727 (1999-11-01), None
patent: 00/57885 (2000-10-01), None
patent: WO 00/71122 (2000-11-01), None
patent: WO 00/72838 (2000-12-01), None
patent: 01/66088 (2001-09-01), None
patent: WO 03/017980 (2003-03-01), None
Amidon, et al., “A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability,”Pharm. Res. 12:413-420 (1995).
Burns, et al., “Formulation Strategies Designed to Maintain the Biphasic Release Characteristics of Liquid-Filled Capsules,”Int. J. Pharm. 141:9-16 (1996).
Shah, et al., “Self-Emulsifying Drug Delivery Systems (SEDDS) with Polyglycolyzed Glycerides for Improving in vitro Dissolution and Oral Absorption of Lipophilic Drugs,”Int. J. Pharm. 106:15-23 (1994).
English language abstract for AH1 above.
Bowtle, et al., “Liquid Filling of Hard Gelatin Capsules: A New Technology for Alternative Formulations,”Phar. Tech. Eur., Oct. 1998, pp. 84-90.
Cole, “Liquid-Filled Hard-Gelatin Capsules,”Pharm. Tech. Intl., Sep./Oct. 1989, pp. 29-33.
Young, “Liquid Fill of Two Piece Hard Shells—A Fluid Solution to Current Problems,”Pharm. Mfg. Packing Sourcer, Mar. 1999, pp. 14-22.
English language abstract of DE 198 01 811 (reference CK).
Bigard et al., “Complete Prevention by Omeprazole of Aspirin Induced Gastric Lesions in Healthy Subjects,”GUT29A712, T49, 1988.
Bombardier et al., “Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis,”N. Engl. J. Med. 343 1520-1528, 2000.
Brown et al., “Prevention of the Gastrointestinal Adverse Effects of Nonsteroidal Anti-Inflammatory Drugs,”Prac. Drug Safety21 503-512, 1999.
Cullen et al., “Primary Gastroduodenal Prophylaxis with Omeprazole for Non-Steroidal Anti-Inflammatory Drug Users,”Aliment. Pharmacol. Ther. 12 135-140, 1998.
Dent, “Why Proton Pump Inhibition Should Heal and Protect Against Nonsteroidal Anti-Inflammatory Drug Ulcers,”Am. J. Med. 104 52S-55S, 1998.
Hawkey, “Progress in Prophylaxis Against Nonsteroidal Anti-Inflammatory Drug-Associated Ulcers and Erosions,”Am. J. Med. 104 67S-74S, 1998.
Hawkey et al., “Omeprazole Compared with Misoprostol for Ulcers Associated with Nonsteroidal Anti-Inflammatory Drugs,”N. Engl. J. Med. 338 727-734, 1998.
Howden, “Clinical Pharmacology of Omeprazole,”Clin. Pharmacokinet. 20 38-49, 1991.
Katz et at, “Gastric Acidity and Acid Breakthrough with Twice-Daily Omeprazole or Iansoprazole,”Aliment. Pharmacol. Ther14 709-714, 2000.
Kephart et al., “Coprescribing of nonsteroidal Anti-Inflammatory Drugs and Cytoprotective and Antiulcer Drugs in Nova Scotia's Senior Population,”Clin. Ther. 17 1159-1173, 1995.
Kimmey et al., “Role of H2-Receptor Blockers in the Prevention of Gastric Injury Resulting from Nonsteroidal Anti-inflammatory Agents,”Am. J. Med. 84 49-52, 1988.
Lad et al., “Management of Nonsteroidal Anti-Inflammatory Drug-Induced Gastroduodenal Disease by Acid Suppression,”Can. J. Gastroenterol13 135-142, 1999.
Lee et al., “Omeprazole Prevents Indomethacin-Induced Gastric Ulcers in Rabbits,”Aliment. Pharmacol. Ther. 10, 571-576, 1996.
Lichtenberger et al., “Nonsteroidal Anti-Inflammatory Drug and Phospholipid Prodrugs: Combination Therapy with Antisecretory Agents in Rats,”Gastroenterology111, 990-995, 1996.
Mattsson et al., “Omeprazole Provides Protection Against Experimentally Induced Gastric Mucosal Lesions,”Eur J. Pharmacol. 91, 111-114, 1983.
Oddsson et al., &
Holmberg Christina
Siekmann Britta
Arent & Fox LLP
Nicox S.A.
Tran S.
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