Self-corrected assay device

Details Self-corrected assay device Self-corrected assay device

1989-08-23

1992-12-15

Housel, James C.

Chemistry: molecular biology and microbiology

Apparatus

Bioreactor

435 11, 435 28, 422 55, 422 56, 436164, 436 13, C12M 136, C12Q 160, G01N 2100

Patent

active

051716887

ABSTRACT:
An assay device and method for determining the concentration of an analyte in a fluid sample. The device includes a porous-matrix reservoir which receives the sample to be assayed, and at least two reaction zones into which sample fluid is drawn from the reservoir. In an embodiment containing two reaction zones, a single-point standard curve which corrects for reduced-signal effects related to loss of reagent activity and linear inhibition effects, is used to determine analyte concentration. In an embodiment containing three reaction zones, a two-point standard curve which corrects for reduced-signal effects related loss of reagent activity and non-linear inhibition effects, is used to determine analyte concentration. Also disclosed is an apparatus which uses the device for automated or semi-automated analyte assay.

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