Self-assembling recombinant papillomavirus capsid proteins

Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...

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435 691, 435 693, 4351723, 4353201, 4352523, 4352402, 4352542, 536 2372, 530350, 4241861, 4242041, C12N 700, C12N 1537, C12N 704

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058719989

ABSTRACT:
Recombinant papillomavirus capsid proteins that are capable of self-assembly into capsomer structures and viral capsids that comprise conformational antigenic epitopes are provided. The capsomer structures and viral capsids, consisting of the capsid proteins that are expression products of a bovine, monkey or human papillomavirus L1 conformational coding sequence proteins, can be prepared as vaccines to induce a high-titer neutralizing antibody response in vertebrate animals. The self assembling capsid proteins can also be used as elements of diagnostic immunoassay procedures for papillomavirus infection.

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