Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...
Patent
1995-06-07
1999-02-16
Mosher, Mary E.
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
435 691, 435 693, 4351723, 4353201, 4352523, 4352402, 4352542, 536 2372, 530350, 4241861, 4242041, C12N 700, C12N 1537, C12N 704
Patent
active
058719989
ABSTRACT:
Recombinant papillomavirus capsid proteins that are capable of self-assembly into capsomer structures and viral capsids that comprise conformational antigenic epitopes are provided. The capsomer structures and viral capsids, consisting of the capsid proteins that are expression products of a bovine, monkey or human papillomavirus L1 conformational coding sequence proteins, can be prepared as vaccines to induce a high-titer neutralizing antibody response in vertebrate animals. The self assembling capsid proteins can also be used as elements of diagnostic immunoassay procedures for papillomavirus infection.
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Howley, P.M., In: Funda
Kirnbauer Reinhard
Lowy Douglas R.
Schiller John T.
Mosher Mary E.
The United States of America as represented by the Department of
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